Effect of an interval rehabilitation program with home-based, vibration-assisted training on the development of muscle and bone in children with cerebral palsy an observational study

I. Duran*, K. Martakis, C. Stark, L. Schafmeyer, M. Rehberg, E. Schoenau

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Web of Science)


Objectives: In children with cerebral palsy (CP), the most common cause of physical impairment in childhood, less muscle and bone growth has been reported, when compared with typically developing children. The aim of this study was to evaluate the effect of an intensive rehabilitation program including physiotherapy in combination with 6 months of home-based, vibration-assisted training on muscle and bone growth in children with CP.Methods: We included children with CP, who participated in a rehabilitation program utilizing whole-body vibration (WBV). Muscle mass was quantified by appendicular lean mass index (App-LMI) and bone mass by total-body-lesshead bone mineral content (TBLH-BMC) assessed by Dual-energy X-ray absorptiometry (DXA) at the beginning of rehabilitation and one year later. To assess the functional muscle-bone unit, the relation of TBLH-BMC to TBLH lean body mass (TBLH-LBM) was used.Results: The study population included 128 children (52 females, mean age 11.9 +/- 2.7). App-LMI assessed in kg/m2 increased significantly after rehabilitation. The age-adjusted Z-score for App-LMI showed no significant change. TBLH-BMC assessed in gram increased significantly. The Z-scores for TBLH-BMC decreased lesser than expected by the evaluation of the cross-sectional data at the beginning of rehabilitation. The parameter TBLH-BMC/TBLH-LBM did not change relevantly after 12 months.Conclusions: Muscle growth and to a lesser extent bone growth could be increased in children with CP. The intensive rehabilitation program including WBV seemed to have no direct effect on the bone, but the observed anabolic effect on the bone, may only been mediated through the muscle.
Original languageEnglish
Pages (from-to)1083-1092
Number of pages10
JournalJournal of Pediatric Endocrinology & Metabolism
Issue number8
Publication statusPublished - 1 Jul 2020


  • adolescents
  • body-composition
  • bone growth
  • cerebral palsy
  • density
  • gross motor function
  • growth
  • high-frequency
  • muscle growth
  • rehabilitation
  • unit
  • whole-body vibration
  • UNIT

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