Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

A. Solomon, R. Handels, A. Wimo, R. Antikainen, T. Laatikainen, E. Levalahti, M. Peltonen, H. Soininen, T. Strandberg, J. Tuomilehto, M. Kivipelto, T. Ngandu*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 % CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.
Original languageEnglish
Pages (from-to)1461-1466
Number of pages6
JournalJournal of Alzheimer's Disease
Volume82
Issue number4
DOIs
Publication statusPublished - 2021

Keywords

  • Clinical trial
  • dementia
  • dementia risk score
  • lifestyle intervention
  • prevention
  • FINNISH GERIATRIC INTERVENTION
  • PREVENT COGNITIVE IMPAIRMENT
  • ALZHEIMERS-DISEASE
  • PREDICTION
  • FINGER
  • TRIALS
  • SCORE

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