Abstract
We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 % CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.
Original language | English |
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Pages (from-to) | 1461-1466 |
Number of pages | 6 |
Journal | Journal of Alzheimer's Disease |
Volume | 82 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- Clinical trial
- dementia
- dementia risk score
- lifestyle intervention
- prevention
- FINNISH GERIATRIC INTERVENTION
- PREVENT COGNITIVE IMPAIRMENT
- ALZHEIMERS-DISEASE
- PREDICTION
- FINGER
- TRIALS
- SCORE