Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

A. Solomon; R. Handels; A. Wimo; R. Antikainen; T. Laatikainen; E. Levalahti; M. Peltonen; H. Soininen; T. Strandberg; J. Tuomilehto; M. Kivipelto; T. Ngandu

doi:10.3233/jad-210331

Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

A. Solomon, R. Handels, A. Wimo, R. Antikainen, T. Laatikainen, E. Levalahti, M. Peltonen, H. Soininen, T. Strandberg, J. Tuomilehto, M. Kivipelto, T. Ngandu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 % CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.

Original language	English
Pages (from-to)	1461-1466
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	82
Issue number	4
DOIs	https://doi.org/10.3233/jad-210331
Publication status	Published - 2021

Keywords

Clinical trial
dementia
dementia risk score
lifestyle intervention
prevention
FINNISH GERIATRIC INTERVENTION
PREVENT COGNITIVE IMPAIRMENT
ALZHEIMERS-DISEASE
PREDICTION
FINGER
TRIALS
SCORE

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Cite this

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title = "Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk",

abstract = "We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 % CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.",

keywords = "Clinical trial, dementia, dementia risk score, lifestyle intervention, prevention, FINNISH GERIATRIC INTERVENTION, PREVENT COGNITIVE IMPAIRMENT, ALZHEIMERS-DISEASE, PREDICTION, FINGER, TRIALS, SCORE",

author = "A. Solomon and R. Handels and A. Wimo and R. Antikainen and T. Laatikainen and E. Levalahti and M. Peltonen and H. Soininen and T. Strandberg and J. Tuomilehto and M. Kivipelto and T. Ngandu",

year = "2021",

doi = "10.3233/jad-210331",

language = "English",

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TY - JOUR

T1 - Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

AU - Solomon, A.

AU - Handels, R.

AU - Wimo, A.

AU - Antikainen, R.

AU - Laatikainen, T.

AU - Levalahti, E.

AU - Peltonen, M.

AU - Soininen, H.

AU - Strandberg, T.

AU - Tuomilehto, J.

AU - Kivipelto, M.

AU - Ngandu, T.

PY - 2021

Y1 - 2021

N2 - We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 % CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.

AB - We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 % CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.

KW - Clinical trial

KW - dementia

KW - dementia risk score

KW - lifestyle intervention

KW - prevention

KW - FINNISH GERIATRIC INTERVENTION

KW - PREVENT COGNITIVE IMPAIRMENT

KW - ALZHEIMERS-DISEASE

KW - PREDICTION

KW - FINGER

KW - TRIALS

KW - SCORE

U2 - 10.3233/jad-210331

DO - 10.3233/jad-210331

M3 - Article

C2 - 34151805

SN - 1387-2877

VL - 82

SP - 1461

EP - 1466

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 4

ER -