Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy

Mickael Martin; Natalie Almeras; Jean-Pierre Despres; Harvey O. Coxson; George R. Washko; Isabelle Vivodtzev; Emiel F. M. Wouters; Erica Rutten; Michelle C. Williams; John T. Murchison; William MacNee; Don D. Sin; Francois Maltais

doi:10.2147/COPD.S124750

Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy

Mickael Martin, Natalie Almeras, Jean-Pierre Despres, Harvey O. Coxson, George R. Washko, Isabelle Vivodtzev, Emiel F. M. Wouters, Erica Rutten, Michelle C. Williams, John T. Murchison, William MacNee, Don D. Sin, Francois Maltais^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Obesity is increasingly associated with COPD, but little is known about the prevalence of ectopic fat accumulation in COPD and whether this can possibly be associated with poor clinical outcomes and comorbidities. The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) substudy tested the hypothesis that COPD is associated with increased ectopic fat accumulation and that this would be associated with COPD-related outcomes and comorbidities.

Methods: Computed tomography (CT) images of the thorax obtained in ECLIPSE were used to quantify ectopic fat accumulation at L2-L3 (eg, cross-sectional area [CSA] of visceral adipose tissue [VAT] and muscle tissue [MT] attenuation, a reflection of muscle fat infiltration) and CSA of MT. A dose-response relationship between CSA of VAT, MT attenuation and CSA of MT and COPD-related outcomes (6-minute walking distance [6MWD], exacerbation rate, quality of life, and forced expiratory volume in 1 second [FEV1] decline) was addressed with the Cochran-Armitage trend test. Regression models were used to investigate possible relationships between CT body composition indices and comorbidities.

Results: From the entire ECLIPSE cohort, we identified 585 subjects with valid CT images at L2-L3 to assess body composition. CSA of VAT was increased (P

Conclusion: Ectopic fat accumulation is increased in COPD, and this was associated with relevant clinical outcomes and comorbidities.

Original language	English
Pages (from-to)	451-460
Number of pages	10
Journal	International journal of chronic obstructive pulmonary disease
Volume	12
DOIs	https://doi.org/10.2147/COPD.S124750
Publication status	Published - 2017

Keywords

metabolic syndrome
obesity
abdominal adiposity
muscle
OBSTRUCTIVE PULMONARY-DISEASE
VISCERAL FAT
SYSTEMIC INFLAMMATION
ABDOMINAL OBESITY
PROGRESSION
MORTALITY
INTERVENTION
ADIPOSITY
IMPACT
COHORT

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Cite this

Martin, M., Almeras, N., Despres, J-P., Coxson, H. O., Washko, G. R., Vivodtzev, I., Wouters, E. F. M., Rutten, E., Williams, M. C., Murchison, J. T., MacNee, W., Sin, D. D., & Maltais, F. (2017). Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy. International journal of chronic obstructive pulmonary disease, 12, 451-460. https://doi.org/10.2147/COPD.S124750

@article{f24e35b456fc40d986107be99a91d428,

title = "Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy",

abstract = "Background: Obesity is increasingly associated with COPD, but little is known about the prevalence of ectopic fat accumulation in COPD and whether this can possibly be associated with poor clinical outcomes and comorbidities. The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) substudy tested the hypothesis that COPD is associated with increased ectopic fat accumulation and that this would be associated with COPD-related outcomes and comorbidities.Methods: Computed tomography (CT) images of the thorax obtained in ECLIPSE were used to quantify ectopic fat accumulation at L2-L3 (eg, cross-sectional area [CSA] of visceral adipose tissue [VAT] and muscle tissue [MT] attenuation, a reflection of muscle fat infiltration) and CSA of MT. A dose-response relationship between CSA of VAT, MT attenuation and CSA of MT and COPD-related outcomes (6-minute walking distance [6MWD], exacerbation rate, quality of life, and forced expiratory volume in 1 second [FEV1] decline) was addressed with the Cochran-Armitage trend test. Regression models were used to investigate possible relationships between CT body composition indices and comorbidities.Results: From the entire ECLIPSE cohort, we identified 585 subjects with valid CT images at L2-L3 to assess body composition. CSA of VAT was increased (PConclusion: Ectopic fat accumulation is increased in COPD, and this was associated with relevant clinical outcomes and comorbidities.",

keywords = "metabolic syndrome, obesity, abdominal adiposity, muscle, OBSTRUCTIVE PULMONARY-DISEASE, VISCERAL FAT, SYSTEMIC INFLAMMATION, ABDOMINAL OBESITY, PROGRESSION, MORTALITY, INTERVENTION, ADIPOSITY, IMPACT, COHORT",

author = "Mickael Martin and Natalie Almeras and Jean-Pierre Despres and Coxson, {Harvey O.} and Washko, {George R.} and Isabelle Vivodtzev and Wouters, {Emiel F. M.} and Erica Rutten and Williams, {Michelle C.} and Murchison, {John T.} and William MacNee and Sin, {Don D.} and Francois Maltais",

year = "2017",

doi = "10.2147/COPD.S124750",

language = "English",

volume = "12",

pages = "451--460",

journal = "International journal of chronic obstructive pulmonary disease",

issn = "1178-2005",

publisher = "Dove Medical Press Ltd",

}

TY - JOUR

T1 - Ectopic fat accumulation in patients with COPD

T2 - an ECLIPSE substudy

AU - Martin, Mickael

AU - Almeras, Natalie

AU - Despres, Jean-Pierre

AU - Coxson, Harvey O.

AU - Washko, George R.

AU - Vivodtzev, Isabelle

AU - Wouters, Emiel F. M.

AU - Rutten, Erica

AU - Williams, Michelle C.

AU - Murchison, John T.

AU - MacNee, William

AU - Sin, Don D.

AU - Maltais, Francois

PY - 2017

Y1 - 2017

N2 - Background: Obesity is increasingly associated with COPD, but little is known about the prevalence of ectopic fat accumulation in COPD and whether this can possibly be associated with poor clinical outcomes and comorbidities. The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) substudy tested the hypothesis that COPD is associated with increased ectopic fat accumulation and that this would be associated with COPD-related outcomes and comorbidities.Methods: Computed tomography (CT) images of the thorax obtained in ECLIPSE were used to quantify ectopic fat accumulation at L2-L3 (eg, cross-sectional area [CSA] of visceral adipose tissue [VAT] and muscle tissue [MT] attenuation, a reflection of muscle fat infiltration) and CSA of MT. A dose-response relationship between CSA of VAT, MT attenuation and CSA of MT and COPD-related outcomes (6-minute walking distance [6MWD], exacerbation rate, quality of life, and forced expiratory volume in 1 second [FEV1] decline) was addressed with the Cochran-Armitage trend test. Regression models were used to investigate possible relationships between CT body composition indices and comorbidities.Results: From the entire ECLIPSE cohort, we identified 585 subjects with valid CT images at L2-L3 to assess body composition. CSA of VAT was increased (PConclusion: Ectopic fat accumulation is increased in COPD, and this was associated with relevant clinical outcomes and comorbidities.

AB - Background: Obesity is increasingly associated with COPD, but little is known about the prevalence of ectopic fat accumulation in COPD and whether this can possibly be associated with poor clinical outcomes and comorbidities. The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) substudy tested the hypothesis that COPD is associated with increased ectopic fat accumulation and that this would be associated with COPD-related outcomes and comorbidities.Methods: Computed tomography (CT) images of the thorax obtained in ECLIPSE were used to quantify ectopic fat accumulation at L2-L3 (eg, cross-sectional area [CSA] of visceral adipose tissue [VAT] and muscle tissue [MT] attenuation, a reflection of muscle fat infiltration) and CSA of MT. A dose-response relationship between CSA of VAT, MT attenuation and CSA of MT and COPD-related outcomes (6-minute walking distance [6MWD], exacerbation rate, quality of life, and forced expiratory volume in 1 second [FEV1] decline) was addressed with the Cochran-Armitage trend test. Regression models were used to investigate possible relationships between CT body composition indices and comorbidities.Results: From the entire ECLIPSE cohort, we identified 585 subjects with valid CT images at L2-L3 to assess body composition. CSA of VAT was increased (PConclusion: Ectopic fat accumulation is increased in COPD, and this was associated with relevant clinical outcomes and comorbidities.

KW - metabolic syndrome

KW - obesity

KW - abdominal adiposity

KW - muscle

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - VISCERAL FAT

KW - SYSTEMIC INFLAMMATION

KW - ABDOMINAL OBESITY

KW - PROGRESSION

KW - MORTALITY

KW - INTERVENTION

KW - ADIPOSITY

KW - IMPACT

KW - COHORT

U2 - 10.2147/COPD.S124750

DO - 10.2147/COPD.S124750

M3 - Article

C2 - 28203068

SN - 1178-2005

VL - 12

SP - 451

EP - 460

JO - International journal of chronic obstructive pulmonary disease

JF - International journal of chronic obstructive pulmonary disease

ER -