Economic evaluation of embryo transfer protocols: Long-term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer

Mirjam M. J. van Heesch

Research output: ThesisDoctoral ThesisInternal

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In the past, more than one embryo was often replaced with IVF to increase the chance of a pregnancy. The flip side is that this also increases the chance of a multiple pregnancy. More and more often only one embryo is replaced because multiple pregnancies are associated with complications for mother and child. In this thesis, the long-term costs and outcomes of singles and multiple births born after IVF have been mapped and used to calculate the long-term cost-effectiveness of various embryo transfer strategies. The replacement of two embryos has the highest chance of success, but is also the most expensive. In terms of cost effectiveness, the preferred strategy depends on the analysis period. From an economic perspective, it is preferable to replace two embryos if the long-term costs and outcomes of the children are included
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Dirksen, Carmen, Supervisor
  • Evers, J.L.H., Supervisor
  • van der Hoeven, M.A.H.B.M, Co-Supervisor
Award date11 Sept 2019
Print ISBNs9789463755252
Publication statusPublished - 2019


  • Fertility problems
  • IVF
  • Embryo replacement policy
  • multiple pregnancy
  • follow-up
  • cost-effectiveness

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