Economic evaluation of an experience sampling method intervention in depression compared with treatment as usual using data from a randomized controlled trial

Claudia J. P. Simons*, Marjan Drukker, Silvia Evers, Ghislaine A. P. G. van Mastrigt, Petra Hohn, Ingrid Kramer, Frenk Peeters, Philippe Delespaul, Claudia Menne-Lothmann, Jessica A. Hartmann, Jim van Os, Marieke Wichers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Experience sampling, a method for real-time self-monitoring of affective experiences, holds opportunities for person-tailored treatment. By focussing on dynamic patterns of positive affect, experience sampling method interventions (ESM-I) accommodate strategies to enhance personalized treatment of depression. at potentially low-costs. This study aimed to investigate the cost-effectiveness of an experience sampling method intervention in patients with depression, from a societal perspective.

Methods: Participants were recruited between January 2010 and February 2012 from out-patient mental health care facilities in or near the Dutch cities of Eindhoven and Maastricht, and through local advertisements. Out-patients diagnosed with major depression (n = 101) receiving pharmacotherapy were randomized into: (i) ESM-I consisting of six weeks of ESM combined with weekly feedback regarding the individual's positive affective experiences, (ii) six weeks of ESM without feedback, or (iii) treatment as usual only. Alongside this randomised controlled trial, an economic evaluation was conducted consisting of a cost-effectiveness and a cost-utility analysis, using Hamilton Depression Rating Scale (HDRS) and quality adjusted life years (QALYs) as outcome, with willingness-to-pay threshold for a QALY set at (sic)50,000 (based on Dutch guidelines for moderate severe to severe illnesses).

Results: The economic evaluation showed that ESM-I is an optimal strategy only when willingness to pay is around (sic)3000 per unit HDRS and around (sic)40,500 per QALY. ESM-I was the least favourable treatment when willingness to pay was lower than (sic)30,000 per QALY. However, at the (sic)50,000 willingness-to-pay threshold, ESM-I was, with a 46% probability, the most favourable treatment (base-case analysis). Sensitivity analyses confirmed the robustness of these results.

Conclusions: We may tentatively conclude that ESM-I is a cost-effective add-on intervention to pharmacotherapy in outpatients with major depression.

Original languageEnglish
Article number415
Number of pages14
JournalBMC Psychiatry
Publication statusPublished - 29 Dec 2017


  • Cost-effectiveness analysis
  • Cost-utility analysis
  • Ecological momentary assessment
  • Experience sampling method
  • Intervention study
  • Psychological feedback
  • Depressive disorder
  • CARE


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