Economic analysis comparing induction of labor and expectant management in women with preterm prelabor rupture of membranes between 34 and 37 weeks (PPROMEXIL trial)

Sylvia M. C. Vijgen*, David P. Van der Ham, Denise Bijlenga, Johannes J. Van Beek, Kitty W. M. Bloemenkamp, Anneke Kwee, Mariet Groenewout, Michael M. Kars, Simone Kuppens, Gerald Mantel, Jan F. M. Molkenboer, Antonius L. M. Mulder, Jan G. Nijhuis, Paula J. M. Pernet, Martina Porath, Mallory D. Woiski, Martin J. N. Weinans, Wim J. Van Wijngaarden, Hajo I. J. Wildschut, Bertina AkerboomJ. Marko Sikkema, Christine Willekes, Ben W. J. Mol, Brent C. Opmeer

*Corresponding author for this work

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Objective To compare the costs of induction of labor and expectant management in women with preterm prelabor rupture of membranes (PPROM). DesignEconomic analysis based on a randomized clinical trial. SettingObstetric departments of eight academic and 52 non-academic hospitals in the Netherlands. PopulationWomen with PPROM near term who were not in labor 24h after PPROM. MethodsA cost-minimization analysis was done from a health care provider perspective, using a bottom-up approach to estimate resource utilization, valued with unit-costs reflecting actual costs. Main outcome measuresPrimary health outcome was the incidence of neonatal sepsis. Direct medical costs were estimated from start of randomization to hospital discharge of mother and child. ResultsInduction of labor did not significantly reduce the probability of neonatal sepsis [2.6% vs. 4.1%, relative risk 0.64 (95% confidence interval 0.25-1.6)]. Mean costs per woman were Euro8094 for induction and Euro7340 for expectant management (difference Euro754; 95% confidence interval -335 to 1802). This difference predominantly originated in the postpartum period, where the mean costs were Euro5669 for induction vs. Euro4801 for expectant management. Delivery costs were higher in women allocated to induction than in women allocated to expectant management (Euro1777 vs. Euro1153 per woman). Antepartum costs in the expectant management group were higher because of longer antepartum maternal stays in hospital. ConclusionsIn women with pregnancies complicated by PPROM near term, induction of labor does not reduce neonatal sepsis, whereas costs associated with this strategy are probably higher.
Original languageEnglish
Pages (from-to)374-381
JournalActa Obstetricia et Gynecologica Scandinavica
Issue number4
Publication statusPublished - Apr 2014


  • Costs
  • induction
  • expectant management
  • labor

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