Abstract

BACKGROUND/AIMS: Placental syndromes (PS) refer to pregnancy complications that include gestational hypertension, (pre)eclampsia, HELLP syndrome, and/or placental insufficiency-induced fetal growth restriction. These disorders are characterized by increased oxidative stress. This study aims to test the hypothesis that the abnormal hemodynamic adaptation to pregnancy, typical for early PS pregnancy, is accompanied by abnormal maternal levels of antioxidants relative to those in normal pregnancy.

METHODS: Before, and at 12, 16, and 20 weeks pregnancy, we measured trolox equivalent antioxidant capacity (TEAC), uric acid (UA), and TEACC (TEAC corrected for UA) in maternal serum of former PS patients, who either developed recurrent PS (rPS; n = 16) or had a normal next pregnancy (non-rPS; n = 23). Concomitantly, we also measured various hemodynamic variables.

RESULTS: rPS differed from non-rPS by higher TEACC levels before pregnancy (178 vs. 152 µM; p = 0.02) and at 20 weeks pregnancy (180 vs. 160 µM; p = 0.04). Only non-rPS responded to pregnancy by significant rises in hemodynamic measures.

CONCLUSION: These data indicate that rPS pregnancies are preceded by an increase in antioxidant capacity, presumably induced by subclinical vascular injury and low-grade chronic inflammation.

Original languageEnglish
Pages (from-to)616-622
Number of pages7
JournalGynecologic and Obstetric Investigation
Volume84
Issue number6
Early online date29 Jul 2019
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Longitudinal
  • Uric acid
  • Preeclampsia
  • Hypertension in pregnancy
  • Pregnancy
  • Antioxidants
  • Trolox equivalent antioxidant capacity
  • OXIDATIVE STRESS
  • HYPERTENSIVE DISEASE
  • UTERINE ARTERY
  • URIC-ACID
  • PREECLAMPSIA
  • WOMEN
  • ONSET
  • ALBUMIN

Cite this

@article{e84a9bd00375473d86360ac99ad3284a,
title = "Early-Pregnancy Circulating Antioxidant Capacity and Hemodynamic Adaptation in Recurrent Placental Syndrome: An Exploratory Study",
abstract = "BACKGROUND/AIMS: Placental syndromes (PS) refer to pregnancy complications that include gestational hypertension, (pre)eclampsia, HELLP syndrome, and/or placental insufficiency-induced fetal growth restriction. These disorders are characterized by increased oxidative stress. This study aims to test the hypothesis that the abnormal hemodynamic adaptation to pregnancy, typical for early PS pregnancy, is accompanied by abnormal maternal levels of antioxidants relative to those in normal pregnancy.METHODS: Before, and at 12, 16, and 20 weeks pregnancy, we measured trolox equivalent antioxidant capacity (TEAC), uric acid (UA), and TEACC (TEAC corrected for UA) in maternal serum of former PS patients, who either developed recurrent PS (rPS; n = 16) or had a normal next pregnancy (non-rPS; n = 23). Concomitantly, we also measured various hemodynamic variables.RESULTS: rPS differed from non-rPS by higher TEACC levels before pregnancy (178 vs. 152 µM; p = 0.02) and at 20 weeks pregnancy (180 vs. 160 µM; p = 0.04). Only non-rPS responded to pregnancy by significant rises in hemodynamic measures.CONCLUSION: These data indicate that rPS pregnancies are preceded by an increase in antioxidant capacity, presumably induced by subclinical vascular injury and low-grade chronic inflammation.",
keywords = "Longitudinal, Uric acid, Preeclampsia, Hypertension in pregnancy, Pregnancy, Antioxidants, Trolox equivalent antioxidant capacity, OXIDATIVE STRESS, HYPERTENSIVE DISEASE, UTERINE ARTERY, URIC-ACID, PREECLAMPSIA, WOMEN, ONSET, ALBUMIN",
author = "Severens-Rijvers, {Carmen A H} and Salwan Al-Nasiry and Annemiek Vincken and Guido Haenen and Bjorn Winkens and Chahinda Ghossein-Doha and Spaanderman, {Marc A E} and Peeters, {Louis L H}",
note = "{\circledC} 2019 The Author(s) Published by S. Karger AG, Basel.",
year = "2019",
month = "11",
doi = "10.1159/000501254",
language = "English",
volume = "84",
pages = "616--622",
journal = "Gynecologic and Obstetric Investigation",
issn = "0378-7346",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - Early-Pregnancy Circulating Antioxidant Capacity and Hemodynamic Adaptation in Recurrent Placental Syndrome

T2 - An Exploratory Study

AU - Severens-Rijvers, Carmen A H

AU - Al-Nasiry, Salwan

AU - Vincken, Annemiek

AU - Haenen, Guido

AU - Winkens, Bjorn

AU - Ghossein-Doha, Chahinda

AU - Spaanderman, Marc A E

AU - Peeters, Louis L H

N1 - © 2019 The Author(s) Published by S. Karger AG, Basel.

PY - 2019/11

Y1 - 2019/11

N2 - BACKGROUND/AIMS: Placental syndromes (PS) refer to pregnancy complications that include gestational hypertension, (pre)eclampsia, HELLP syndrome, and/or placental insufficiency-induced fetal growth restriction. These disorders are characterized by increased oxidative stress. This study aims to test the hypothesis that the abnormal hemodynamic adaptation to pregnancy, typical for early PS pregnancy, is accompanied by abnormal maternal levels of antioxidants relative to those in normal pregnancy.METHODS: Before, and at 12, 16, and 20 weeks pregnancy, we measured trolox equivalent antioxidant capacity (TEAC), uric acid (UA), and TEACC (TEAC corrected for UA) in maternal serum of former PS patients, who either developed recurrent PS (rPS; n = 16) or had a normal next pregnancy (non-rPS; n = 23). Concomitantly, we also measured various hemodynamic variables.RESULTS: rPS differed from non-rPS by higher TEACC levels before pregnancy (178 vs. 152 µM; p = 0.02) and at 20 weeks pregnancy (180 vs. 160 µM; p = 0.04). Only non-rPS responded to pregnancy by significant rises in hemodynamic measures.CONCLUSION: These data indicate that rPS pregnancies are preceded by an increase in antioxidant capacity, presumably induced by subclinical vascular injury and low-grade chronic inflammation.

AB - BACKGROUND/AIMS: Placental syndromes (PS) refer to pregnancy complications that include gestational hypertension, (pre)eclampsia, HELLP syndrome, and/or placental insufficiency-induced fetal growth restriction. These disorders are characterized by increased oxidative stress. This study aims to test the hypothesis that the abnormal hemodynamic adaptation to pregnancy, typical for early PS pregnancy, is accompanied by abnormal maternal levels of antioxidants relative to those in normal pregnancy.METHODS: Before, and at 12, 16, and 20 weeks pregnancy, we measured trolox equivalent antioxidant capacity (TEAC), uric acid (UA), and TEACC (TEAC corrected for UA) in maternal serum of former PS patients, who either developed recurrent PS (rPS; n = 16) or had a normal next pregnancy (non-rPS; n = 23). Concomitantly, we also measured various hemodynamic variables.RESULTS: rPS differed from non-rPS by higher TEACC levels before pregnancy (178 vs. 152 µM; p = 0.02) and at 20 weeks pregnancy (180 vs. 160 µM; p = 0.04). Only non-rPS responded to pregnancy by significant rises in hemodynamic measures.CONCLUSION: These data indicate that rPS pregnancies are preceded by an increase in antioxidant capacity, presumably induced by subclinical vascular injury and low-grade chronic inflammation.

KW - Longitudinal

KW - Uric acid

KW - Preeclampsia

KW - Hypertension in pregnancy

KW - Pregnancy

KW - Antioxidants

KW - Trolox equivalent antioxidant capacity

KW - OXIDATIVE STRESS

KW - HYPERTENSIVE DISEASE

KW - UTERINE ARTERY

KW - URIC-ACID

KW - PREECLAMPSIA

KW - WOMEN

KW - ONSET

KW - ALBUMIN

U2 - 10.1159/000501254

DO - 10.1159/000501254

M3 - Article

C2 - 31357192

VL - 84

SP - 616

EP - 622

JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

SN - 0378-7346

IS - 6

ER -