Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study

Supriya Misra; Bizu Gelaye; Karestan C. Koenen; David R. Williams; Christina P. C. Borba; Diego Quattrone; Marta Di Forti; Caterina La Cascia; Daniele La Barbera; Ilaria Tarricone; Domenico Berardi; Andrei Szoke; Celso Arango; Andrea Tortelli; Lieuwe de Haan; Eva Velthorst; Julio Bobes; Miguel Bernardo; Julio Sanjuan; Jose Luis Santos; Manuel Arrojo; Cristina Marta Del-Ben; Paulo Rossi Menezes; Jean-Paul Selten; Peter B. Jones; James B. Kirkbride; Bart P. E. Rutten; Jim van Os; Robin M. Murray; Charlotte Gayer-Anderson; Craig Morgan; EU-GEI WP2 Group

doi:10.3390/jcm8071081

Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study

Supriya Misra^*, Bizu Gelaye, Karestan C. Koenen, David R. Williams, Christina P. C. Borba, Diego Quattrone, Marta Di Forti, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Andrei Szoke, Celso Arango, Andrea Tortelli, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel Bernardo, Julio Sanjuan, Jose Luis SantosManuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, Peter B. Jones, James B. Kirkbride, Bart P. E. Rutten, Jim van Os, Robin M. Murray, Charlotte Gayer-Anderson, Craig Morgan, EU-GEI WP2 Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal, paternal, both), and child's age at death with psychosis, both overall and by ethnic group. In fully adjusted multivariable mixed-effects logistic regression models, experiencing early parental death was associated with 1.54-fold greater odds of psychosis (95% confidence interval (CI): 1.23, 1.92). Experiencing maternal death had 2.27-fold greater odds (95% CI: 1.18, 4.37), paternal death had 1.14-fold greater odds (95% CI: 0.79, 1.64), and both deaths had 4.42-fold greater odds (95% CI: 2.57, 7.60) of psychosis compared with no early parental death. Experiencing parental death between 11 and 16 years of age had 2.03-fold greater odds of psychosis than experiencing it before five years of age (95% CI: 1.02, 4.04). In stratified analyses, experiencing the death of both parents had 9.22-fold greater odds of psychosis among minority ethnic groups (95% CI: 2.02-28.02) and no elevated odds among the ethnic majority (odds ratio (OR): 0.96; 95% CI: 0.10-8.97), which could be due in part to the higher prevalence of early parental death among minority ethnic groups but should be interpreted cautiously given the wide confidence intervals.

Original language	English
Article number	1081
Number of pages	13
Journal	Journal of Clinical Medicine
Volume	8
Issue number	7
DOIs	https://doi.org/10.3390/jcm8071081
Publication status	Published - Jul 2019

Keywords

childhood adversities
early parental death
early bereavement
ethnic minorities
psychosis
schizophrenia
population-based
case-control
multi-country
CHILDHOOD
SCHIZOPHRENIA
HEALTH
BEREAVEMENT
DISADVANTAGE
METAANALYSIS
DISORDERS
MORTALITY
STRESS
RACE

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Misra, S., Gelaye, B., Koenen, K. C., Williams, D. R., Borba, C. P. C., Quattrone, D., Di Forti, M., La Cascia, C., La Barbera, D., Tarricone, I., Berardi, D., Szoke, A., Arango, C., Tortelli, A., de Haan, L., Velthorst, E., Bobes, J., Bernardo, M., Sanjuan, J., ... EU-GEI WP2 Group (2019). Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study. Journal of Clinical Medicine, 8(7), Article 1081. https://doi.org/10.3390/jcm8071081

@article{a2ed6b13fe9c49d288dbcb1c0dca8926,

title = "Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study",

abstract = "Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal, paternal, both), and child's age at death with psychosis, both overall and by ethnic group. In fully adjusted multivariable mixed-effects logistic regression models, experiencing early parental death was associated with 1.54-fold greater odds of psychosis (95% confidence interval (CI): 1.23, 1.92). Experiencing maternal death had 2.27-fold greater odds (95% CI: 1.18, 4.37), paternal death had 1.14-fold greater odds (95% CI: 0.79, 1.64), and both deaths had 4.42-fold greater odds (95% CI: 2.57, 7.60) of psychosis compared with no early parental death. Experiencing parental death between 11 and 16 years of age had 2.03-fold greater odds of psychosis than experiencing it before five years of age (95% CI: 1.02, 4.04). In stratified analyses, experiencing the death of both parents had 9.22-fold greater odds of psychosis among minority ethnic groups (95% CI: 2.02-28.02) and no elevated odds among the ethnic majority (odds ratio (OR): 0.96; 95% CI: 0.10-8.97), which could be due in part to the higher prevalence of early parental death among minority ethnic groups but should be interpreted cautiously given the wide confidence intervals.",

keywords = "childhood adversities, early parental death, early bereavement, ethnic minorities, psychosis, schizophrenia, population-based, case-control, multi-country, CHILDHOOD, SCHIZOPHRENIA, HEALTH, BEREAVEMENT, DISADVANTAGE, METAANALYSIS, DISORDERS, MORTALITY, STRESS, RACE",

author = "Supriya Misra and Bizu Gelaye and Koenen, {Karestan C.} and Williams, {David R.} and Borba, {Christina P. C.} and Diego Quattrone and {Di Forti}, Marta and {La Cascia}, Caterina and {La Barbera}, Daniele and Ilaria Tarricone and Domenico Berardi and Andrei Szoke and Celso Arango and Andrea Tortelli and {de Haan}, Lieuwe and Eva Velthorst and Julio Bobes and Miguel Bernardo and Julio Sanjuan and {Luis Santos}, Jose and Manuel Arrojo and Del-Ben, {Cristina Marta} and {Rossi Menezes}, Paulo and Jean-Paul Selten and Jones, {Peter B.} and Kirkbride, {James B.} and Rutten, {Bart P. E.} and {van Os}, Jim and Murray, {Robin M.} and Charlotte Gayer-Anderson and Craig Morgan and {EU-GEI WP2 Group}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jul,

doi = "10.3390/jcm8071081",

language = "English",

volume = "8",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

Misra, S, Gelaye, B, Koenen, KC, Williams, DR, Borba, CPC, Quattrone, D, Di Forti, M, La Cascia, C, La Barbera, D, Tarricone, I, Berardi, D, Szoke, A, Arango, C, Tortelli, A, de Haan, L, Velthorst, E, Bobes, J, Bernardo, M, Sanjuan, J, Luis Santos, J, Arrojo, M, Del-Ben, CM, Rossi Menezes, P, Selten, J-P, Jones, PB, Kirkbride, JB, Rutten, BPE, van Os, J, Murray, RM, Gayer-Anderson, C, Morgan, C & EU-GEI WP2 Group 2019, 'Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study', Journal of Clinical Medicine, vol. 8, no. 7, 1081. https://doi.org/10.3390/jcm8071081

TY - JOUR

T1 - Early Parental Death and Risk of Psychosis in Offspring

T2 - A Six-Country Case-Control Study

AU - Misra, Supriya

AU - Gelaye, Bizu

AU - Koenen, Karestan C.

AU - Williams, David R.

AU - Borba, Christina P. C.

AU - Quattrone, Diego

AU - Di Forti, Marta

AU - La Cascia, Caterina

AU - La Barbera, Daniele

AU - Tarricone, Ilaria

AU - Berardi, Domenico

AU - Szoke, Andrei

AU - Arango, Celso

AU - Tortelli, Andrea

AU - de Haan, Lieuwe

AU - Velthorst, Eva

AU - Bobes, Julio

AU - Bernardo, Miguel

AU - Sanjuan, Julio

AU - Luis Santos, Jose

AU - Arrojo, Manuel

AU - Del-Ben, Cristina Marta

AU - Rossi Menezes, Paulo

AU - Selten, Jean-Paul

AU - Jones, Peter B.

AU - Kirkbride, James B.

AU - Rutten, Bart P. E.

AU - van Os, Jim

AU - Murray, Robin M.

AU - Gayer-Anderson, Charlotte

AU - Morgan, Craig

AU - EU-GEI WP2 Group

PY - 2019/7

Y1 - 2019/7

N2 - Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal, paternal, both), and child's age at death with psychosis, both overall and by ethnic group. In fully adjusted multivariable mixed-effects logistic regression models, experiencing early parental death was associated with 1.54-fold greater odds of psychosis (95% confidence interval (CI): 1.23, 1.92). Experiencing maternal death had 2.27-fold greater odds (95% CI: 1.18, 4.37), paternal death had 1.14-fold greater odds (95% CI: 0.79, 1.64), and both deaths had 4.42-fold greater odds (95% CI: 2.57, 7.60) of psychosis compared with no early parental death. Experiencing parental death between 11 and 16 years of age had 2.03-fold greater odds of psychosis than experiencing it before five years of age (95% CI: 1.02, 4.04). In stratified analyses, experiencing the death of both parents had 9.22-fold greater odds of psychosis among minority ethnic groups (95% CI: 2.02-28.02) and no elevated odds among the ethnic majority (odds ratio (OR): 0.96; 95% CI: 0.10-8.97), which could be due in part to the higher prevalence of early parental death among minority ethnic groups but should be interpreted cautiously given the wide confidence intervals.

AB - Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal, paternal, both), and child's age at death with psychosis, both overall and by ethnic group. In fully adjusted multivariable mixed-effects logistic regression models, experiencing early parental death was associated with 1.54-fold greater odds of psychosis (95% confidence interval (CI): 1.23, 1.92). Experiencing maternal death had 2.27-fold greater odds (95% CI: 1.18, 4.37), paternal death had 1.14-fold greater odds (95% CI: 0.79, 1.64), and both deaths had 4.42-fold greater odds (95% CI: 2.57, 7.60) of psychosis compared with no early parental death. Experiencing parental death between 11 and 16 years of age had 2.03-fold greater odds of psychosis than experiencing it before five years of age (95% CI: 1.02, 4.04). In stratified analyses, experiencing the death of both parents had 9.22-fold greater odds of psychosis among minority ethnic groups (95% CI: 2.02-28.02) and no elevated odds among the ethnic majority (odds ratio (OR): 0.96; 95% CI: 0.10-8.97), which could be due in part to the higher prevalence of early parental death among minority ethnic groups but should be interpreted cautiously given the wide confidence intervals.

KW - childhood adversities

KW - early parental death

KW - early bereavement

KW - ethnic minorities

KW - psychosis

KW - schizophrenia

KW - population-based

KW - case-control

KW - multi-country

KW - CHILDHOOD

KW - SCHIZOPHRENIA

KW - HEALTH

KW - BEREAVEMENT

KW - DISADVANTAGE

KW - METAANALYSIS

KW - DISORDERS

KW - MORTALITY

KW - STRESS

KW - RACE

U2 - 10.3390/jcm8071081

DO - 10.3390/jcm8071081

M3 - Article

C2 - 31340495

SN - 2077-0383

VL - 8

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 7

M1 - 1081

ER -