Early outcomes following isolated coronary artery bypass surgery: Influence of peripheral artery disease

Massimo Bonacchi*, Orlando Parise, Francesco Matteucci, Cecilia Tetta, Amalia Ioanna Moula, Linda Renata Micali, Edvin Prifti, Guido Sani, Sandro Gelsomino

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Background We carried out a propensity score-based analysis on early outcomes after coronary artery bypass grafting (CABG) in patients with and without peripheral artery disease (PAD). Materials and Methods A total of 11 311 patients undergoing isolated CABG between 1997 and 2017 were included in the study. Patients were divided into two groups based on whether they were affected (n = 1961) or not affected (n = 9350) by PAD. Inverse probability of treatment weighting was employed to reduce confounding preoperative and operative variables. The main endpoints were death, cardiac death, stroke, and limb ischemia requiring percutaneous or surgical revascularization. Results The excellent balance was obtained, and the groups were very similar. For death and cardiac death, there were no differences between patients with and without PAD (P = .06 and P = .179, respectively). In contrast, PAD patients showed a higher incidence of stroke (P = .04), acute kidney disease (AKD) (P = .003) and limb ischemia requiring intervention (P <.001) than patients without PAD. Conclusions The presence of peripheral arterial disease increases the incidence of postoperative stroke, AKD and limb ischemia requiring intervention, independent of patient characteristics, concomitant risk factors, surgical approaches, and techniques. Further larger studies are necessary to confirm our findings.

Original languageEnglish
Pages (from-to)1470-1477
Number of pages8
JournalJournal of Cardiac Surgery
Volume34
Issue number12
Early online date19 Sep 2019
DOIs
Publication statusPublished - Dec 2019

Keywords

  • coronary artery bypass
  • peripheral arterial disease
  • peripheral vascular disease
  • LONG-TERM SURVIVAL
  • VASCULAR-DISEASE
  • PERIOPERATIVE STROKE
  • OCCLUSIVE DISEASE
  • REVASCULARIZATION
  • MORTALITY
  • STENOSIS

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