TY - JOUR
T1 - Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation
AU - Pluymaekers, Nikki A. H. A.
AU - Dudink, Elton A. M. P.
AU - Luermans, Justin G. L. M.
AU - Meeder, Joan G.
AU - Lenderink, Timo
AU - Widdershoven, Jos
AU - Bucx, Jeroen J. J.
AU - Rienstra, Michiel
AU - Kamp, Otto
AU - Van Opstal, Jurren M.
AU - Alings, Marco
AU - Oomen, Anton
AU - Kirchhof, Charles J.
AU - Van Dijk, Vincent F.
AU - Ramanna, Hemanth
AU - Liem, Anho
AU - Dekker, Lukas R.
AU - Essers, Brigitte A. B.
AU - Tijssen, Jan G. P.
AU - Van Gelder, Isabelle C.
AU - Crijns, Harry J. G. M.
AU - RACE 7 ACWAS Investigators
N1 - Funding Information:
Staff members of the independent Clinical Trial Center Maastricht performed the trial monitoring and data management. The trial was supported by the Netherlands Organization for Health Research and Development–Health Care Efficiency Research Program and Maastricht University Medical Center. Boehringer Ingelheim provided some devices for remote monitoring of patients by electrocardiography (ECG) but had no role in the design or execution of the trial; company representatives did not review the protocol or the manuscript. Investigators from the Department of Cardiology affiliated with the Heart and Vascular Center at the Maastricht University Medical Center designed the trial, collected and managed the data, and performed the statistical analyses. The writing committee wrote the manuscript, and all the steering committee members made the decision to submit it for publication. The authors had unrestricted access to the data and vouch for the accuracy and completeness of the data and analyses and for the fidelity of the trial to the protocol.
Publisher Copyright:
© 2019 Massachusetts Medical Society.
PY - 2019/4/18
Y1 - 2019/4/18
N2 - Background Patients with recent-onset atrial fibrillation commonly undergo immediate restoration of sinus rhythm by pharmacologic or electrical cardioversion. However, whether immediate restoration of sinus rhythm is necessary is not known, since atrial fibrillation often terminates spontaneously. Methods In a multicenter, randomized, open-label, noninferiority trial, we randomly assigned patients with hemodynamically stable, recent-onset (
AB - Background Patients with recent-onset atrial fibrillation commonly undergo immediate restoration of sinus rhythm by pharmacologic or electrical cardioversion. However, whether immediate restoration of sinus rhythm is necessary is not known, since atrial fibrillation often terminates spontaneously. Methods In a multicenter, randomized, open-label, noninferiority trial, we randomly assigned patients with hemodynamically stable, recent-onset (
KW - ABLATION
KW - ANTICOAGULATION
KW - CATHETER
KW - DESIGN
KW - ECHOCARDIOGRAPHY
KW - GUIDELINES
KW - MANAGEMENT
KW - SPONTANEOUS CONVERSION
KW - STROKE
KW - TEMPORAL RELATIONSHIP
KW - DEVICE
U2 - 10.1056/NEJMoa1900353
DO - 10.1056/NEJMoa1900353
M3 - Article
SN - 0028-4793
VL - 380
SP - 1499
EP - 1508
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 16
ER -