Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis

Sanne M. Dorhout Mees; Ale Algra; George K. C. Wong; Wai S. Poon; Celia M. Bradford; Jeffrey L. Saver; Sidney Starkman; Gabriel J. E. Rinkel; Walter M. van den Bergh

doi:10.1161/STROKEAHA.115.010575

Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis

Sanne M. Dorhout Mees, Ale Algra, George K. C. Wong, Wai S. Poon, Celia M. Bradford, Jeffrey L. Saver, Sidney Starkman, Gabriel J. E. Rinkel, Walter M. van den Bergh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Delayed cerebral ischemia (DCI) is an important cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Trials of magnesium treatment starting 24 hours. We calculated adjusted risk ratios with corresponding 95% confidence intervals for magnesium versus placebo treatment for poor outcome and DCI.We included 5 trials totaling 1981 patients; 83 patients started treatment24 hours 1.06 (0.87-1.31), and for DCI, 24 hours 1.08 (0.88-1.32).This meta-analysis suggests no beneficial effect of magnesium treatment on poor outcome or DCI when started early after SAH onset. Although the number of patients was small and a beneficial effect cannot be definitively excluded, we found no justification for a new trial with early magnesium treatment after SAH.? 2015 American Heart Association, Inc.

Original language	English
Pages (from-to)	3190-3193
Journal	Stroke
Volume	46
Issue number	11
DOIs	https://doi.org/10.1161/STROKEAHA.115.010575
Publication status	Published - Nov 2015

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title = "Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis",

abstract = "Delayed cerebral ischemia (DCI) is an important cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Trials of magnesium treatment starting 24 hours. We calculated adjusted risk ratios with corresponding 95% confidence intervals for magnesium versus placebo treatment for poor outcome and DCI.We included 5 trials totaling 1981 patients; 83 patients started treatment24 hours 1.06 (0.87-1.31), and for DCI, 24 hours 1.08 (0.88-1.32).This meta-analysis suggests no beneficial effect of magnesium treatment on poor outcome or DCI when started early after SAH onset. Although the number of patients was small and a beneficial effect cannot be definitively excluded, we found no justification for a new trial with early magnesium treatment after SAH.? 2015 American Heart Association, Inc.",

author = "Mees, {Sanne M. Dorhout} and Ale Algra and Wong, {George K. C.} and Poon, {Wai S.} and Bradford, {Celia M.} and Saver, {Jeffrey L.} and Sidney Starkman and Rinkel, {Gabriel J. E.} and {van den Bergh}, {Walter M.}",

year = "2015",

month = nov,

doi = "10.1161/STROKEAHA.115.010575",

language = "English",

volume = "46",

pages = "3190--3193",

journal = "Stroke",

issn = "0039-2499",

publisher = "Wolters Kluwer Health",

number = "11",

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TY - JOUR

T1 - Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage

T2 - Individual Patient Data Meta-Analysis

AU - Mees, Sanne M. Dorhout

AU - Algra, Ale

AU - Wong, George K. C.

AU - Poon, Wai S.

AU - Bradford, Celia M.

AU - Saver, Jeffrey L.

AU - Starkman, Sidney

AU - Rinkel, Gabriel J. E.

AU - van den Bergh, Walter M.

PY - 2015/11

Y1 - 2015/11

N2 - Delayed cerebral ischemia (DCI) is an important cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Trials of magnesium treatment starting 24 hours. We calculated adjusted risk ratios with corresponding 95% confidence intervals for magnesium versus placebo treatment for poor outcome and DCI.We included 5 trials totaling 1981 patients; 83 patients started treatment24 hours 1.06 (0.87-1.31), and for DCI, 24 hours 1.08 (0.88-1.32).This meta-analysis suggests no beneficial effect of magnesium treatment on poor outcome or DCI when started early after SAH onset. Although the number of patients was small and a beneficial effect cannot be definitively excluded, we found no justification for a new trial with early magnesium treatment after SAH.? 2015 American Heart Association, Inc.

AB - Delayed cerebral ischemia (DCI) is an important cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Trials of magnesium treatment starting 24 hours. We calculated adjusted risk ratios with corresponding 95% confidence intervals for magnesium versus placebo treatment for poor outcome and DCI.We included 5 trials totaling 1981 patients; 83 patients started treatment24 hours 1.06 (0.87-1.31), and for DCI, 24 hours 1.08 (0.88-1.32).This meta-analysis suggests no beneficial effect of magnesium treatment on poor outcome or DCI when started early after SAH onset. Although the number of patients was small and a beneficial effect cannot be definitively excluded, we found no justification for a new trial with early magnesium treatment after SAH.? 2015 American Heart Association, Inc.

U2 - 10.1161/STROKEAHA.115.010575

DO - 10.1161/STROKEAHA.115.010575

M3 - Article

C2 - 26463689

SN - 0039-2499

VL - 46

SP - 3190

EP - 3193

JO - Stroke

JF - Stroke

IS - 11

ER -

Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis

Abstract

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