Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis

Sanne M. Dorhout Mees, Ale Algra, George K. C. Wong, Wai S. Poon, Celia M. Bradford, Jeffrey L. Saver, Sidney Starkman, Gabriel J. E. Rinkel, Walter M. van den Bergh*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)


Delayed cerebral ischemia (DCI) is an important cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Trials of magnesium treatment starting 24 hours. We calculated adjusted risk ratios with corresponding 95% confidence intervals for magnesium versus placebo treatment for poor outcome and DCI.We included 5 trials totaling 1981 patients; 83 patients started treatment24 hours 1.06 (0.87-1.31), and for DCI, 24 hours 1.08 (0.88-1.32).This meta-analysis suggests no beneficial effect of magnesium treatment on poor outcome or DCI when started early after SAH onset. Although the number of patients was small and a beneficial effect cannot be definitively excluded, we found no justification for a new trial with early magnesium treatment after SAH.? 2015 American Heart Association, Inc.
Original languageEnglish
Pages (from-to)3190-3193
Issue number11
Publication statusPublished - Nov 2015

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