Early-Life Environmental Exposures and Blood Pressure in Children

Charline Warembourg; Lea Maitre; Ibon Tamayo-Uria; Serena Fossati; Theano Roumeliotaki; Gunn Marit Aasvang; Sandra Andrusaityte; Maribel Casas; Enrique Cequier; Lida Chatzi; Audrius Dedele; Juan-Ramon Gonzalez; Regina Grazuleviciene; Line Smastuen Haug; Carles Hernandez-Ferrer; Barbara Heude; Marianna Karachaliou; Norun Hjertager Krog; Rosemary McEachan; Mark Nieuwenhuijsen; Inga Petraviciene; Joane Quentin; Oliver Robinson; Amrit Kaur Sakhi; Remy Slama; Cathrine Thomsen; Jose Urquiza; Marina Vafeiadi; Jane West; John Wright; Martine Vrijheid; Xavier Basagana

doi:10.1016/j.jacc.2019.06.069

Early-Life Environmental Exposures and Blood Pressure in Children

Charline Warembourg, Lea Maitre, Ibon Tamayo-Uria, Serena Fossati, Theano Roumeliotaki, Gunn Marit Aasvang, Sandra Andrusaityte, Maribel Casas, Enrique Cequier, Lida Chatzi, Audrius Dedele, Juan-Ramon Gonzalez, Regina Grazuleviciene, Line Smastuen Haug, Carles Hernandez-Ferrer, Barbara Heude, Marianna Karachaliou, Norun Hjertager Krog, Rosemary McEachan, Mark NieuwenhuijsenInga Petraviciene, Joane Quentin, Oliver Robinson, Amrit Kaur Sakhi, Remy Slama, Cathrine Thomsen, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Martine Vrijheid, Xavier Basagana^*

^*Corresponding author for this work

NUTRIM - Respiratory & Age-related Health

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously.

OBJECTIVES This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children.

METHODS Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously.

RESULTS Decreases in systolic BP were observed with facility density (beta change for an interquartile-range increase in exposure: -1.7 mm Hg [95% confidence interval (CI): -2.5 to -0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (-1.4 mm Hg [95% CI: -2.6 to -0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: -1.6 mm Hg [95% CI: -2.4 to -0.7 mm Hg]), hexachlorobenzene (-1.5 mm Hg [95% CI: -2.4 to -0.6 mm Hg]), and mono -benzyl phthalate (-0.7 mm Hg [95% CI: -1.3 to -0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examination (-1.4 mm Hg [95% CI: -2.3 to -0.5 mm Hg]) and child DDE concentrations (-1.1 mm Hg [95% CI: -1.9 to -0.3 mm Hg]), whereas increases in diastolic BP were observed with maternal bisphenol-A concentrations (0.7 mm Hg [95% CI: 0.1 to 1.4 mm Hg]), high fish intake during pregnancy (1.2 mm Hg [95% CI: -0.2 to 2.7 mm Hg]), and child copper concentrations (0.9 mm Hg [95% CI: 0.3 to 1.6 mm Hg]).

CONCLUSIONS This study suggests that early-life exposure to several chemicals, as well as built environment and meteorological factors, may affect BP in children. (C) 2019 by the American College of Cardiology Foundation.

Original language	English
Pages (from-to)	1317-1328
Number of pages	12
Journal	Journal of the American College of Cardiology
Volume	74
Issue number	10
DOIs	https://doi.org/10.1016/j.jacc.2019.06.069
Publication status	Published - 10 Sept 2019

Keywords

blood pressure
chemicals
children
cohort
environment
epidemiology
exposome
PERSISTENT ORGANIC POLLUTANTS
CARDIOMETABOLIC TRAITS
BISPHENOL-A
IN-UTERO
ASSOCIATION
EXPOSOME
CHILDHOOD
MOTHER
ADOLESCENTS
OBESITY

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Warembourg, C., Maitre, L., Tamayo-Uria, I., Fossati, S., Roumeliotaki, T., Aasvang, G. M., Andrusaityte, S., Casas, M., Cequier, E., Chatzi, L., Dedele, A., Gonzalez, J.-R., Grazuleviciene, R., Haug, L. S., Hernandez-Ferrer, C., Heude, B., Karachaliou, M., Krog, N. H., McEachan, R., ... Basagana, X. (2019). Early-Life Environmental Exposures and Blood Pressure in Children. Journal of the American College of Cardiology, 74(10), 1317-1328. https://doi.org/10.1016/j.jacc.2019.06.069

@article{9d1d7c24a9a141d2a7f448b50d5aafc3,

title = "Early-Life Environmental Exposures and Blood Pressure in Children",

abstract = "BACKGROUND Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously.OBJECTIVES This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children.METHODS Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously.RESULTS Decreases in systolic BP were observed with facility density (beta change for an interquartile-range increase in exposure: -1.7 mm Hg [95% confidence interval (CI): -2.5 to -0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (-1.4 mm Hg [95% CI: -2.6 to -0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: -1.6 mm Hg [95% CI: -2.4 to -0.7 mm Hg]), hexachlorobenzene (-1.5 mm Hg [95% CI: -2.4 to -0.6 mm Hg]), and mono -benzyl phthalate (-0.7 mm Hg [95% CI: -1.3 to -0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examination (-1.4 mm Hg [95% CI: -2.3 to -0.5 mm Hg]) and child DDE concentrations (-1.1 mm Hg [95% CI: -1.9 to -0.3 mm Hg]), whereas increases in diastolic BP were observed with maternal bisphenol-A concentrations (0.7 mm Hg [95% CI: 0.1 to 1.4 mm Hg]), high fish intake during pregnancy (1.2 mm Hg [95% CI: -0.2 to 2.7 mm Hg]), and child copper concentrations (0.9 mm Hg [95% CI: 0.3 to 1.6 mm Hg]).CONCLUSIONS This study suggests that early-life exposure to several chemicals, as well as built environment and meteorological factors, may affect BP in children. (C) 2019 by the American College of Cardiology Foundation.",

keywords = "blood pressure, chemicals, children, cohort, environment, epidemiology, exposome, PERSISTENT ORGANIC POLLUTANTS, CARDIOMETABOLIC TRAITS, BISPHENOL-A, IN-UTERO, ASSOCIATION, EXPOSOME, CHILDHOOD, MOTHER, ADOLESCENTS, OBESITY",

author = "Charline Warembourg and Lea Maitre and Ibon Tamayo-Uria and Serena Fossati and Theano Roumeliotaki and Aasvang, {Gunn Marit} and Sandra Andrusaityte and Maribel Casas and Enrique Cequier and Lida Chatzi and Audrius Dedele and Juan-Ramon Gonzalez and Regina Grazuleviciene and Haug, {Line Smastuen} and Carles Hernandez-Ferrer and Barbara Heude and Marianna Karachaliou and Krog, {Norun Hjertager} and Rosemary McEachan and Mark Nieuwenhuijsen and Inga Petraviciene and Joane Quentin and Oliver Robinson and Sakhi, {Amrit Kaur} and Remy Slama and Cathrine Thomsen and Jose Urquiza and Marina Vafeiadi and Jane West and John Wright and Martine Vrijheid and Xavier Basagana",

note = "Funding Information: ISGlobal is a member of the Agency for the Research Centres of Catalonia (CERCA) Programme, Generalitat de Catalunya. The authors are grateful to all of the participating children, parents, practitioners, and researchers in the 6 countries who took part in this study. The authors further thank Muireann Coen, Sonia Brishoual, Angelique Serre, Michele Grosdenier, Prof. Frederic Millot, Elodie Migault, Manuela Boue, Sandy Bertin, Veronique Ferrand-Rigalleau, C{\'e}line Leger, Noella Gorry, Silvia Fochs, Nuria Pey, Cecilia Persavente, Susana Gross, Georgia Chalkiadaki, Danai Feida, Eirini Michalaki, Mariza Kampouri, Anny Kyriklaki, Minas Iakovidis, Maria Fasoulaki, Ingvild Essen, Heidi Marie Nordheim, and the Yorkshire Water. Publisher Copyright: {\textcopyright} 2019 American College of Cardiology Foundation",

year = "2019",

month = sep,

day = "10",

doi = "10.1016/j.jacc.2019.06.069",

language = "English",

volume = "74",

pages = "1317--1328",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier Inc.",

number = "10",

}

Warembourg, C, Maitre, L, Tamayo-Uria, I, Fossati, S, Roumeliotaki, T, Aasvang, GM, Andrusaityte, S, Casas, M, Cequier, E, Chatzi, L, Dedele, A, Gonzalez, J-R, Grazuleviciene, R, Haug, LS, Hernandez-Ferrer, C, Heude, B, Karachaliou, M, Krog, NH, McEachan, R, Nieuwenhuijsen, M, Petraviciene, I, Quentin, J, Robinson, O, Sakhi, AK, Slama, R, Thomsen, C, Urquiza, J, Vafeiadi, M, West, J, Wright, J, Vrijheid, M & Basagana, X 2019, 'Early-Life Environmental Exposures and Blood Pressure in Children', Journal of the American College of Cardiology, vol. 74, no. 10, pp. 1317-1328. https://doi.org/10.1016/j.jacc.2019.06.069

TY - JOUR

T1 - Early-Life Environmental Exposures and Blood Pressure in Children

AU - Warembourg, Charline

AU - Maitre, Lea

AU - Tamayo-Uria, Ibon

AU - Fossati, Serena

AU - Roumeliotaki, Theano

AU - Aasvang, Gunn Marit

AU - Andrusaityte, Sandra

AU - Casas, Maribel

AU - Cequier, Enrique

AU - Chatzi, Lida

AU - Dedele, Audrius

AU - Gonzalez, Juan-Ramon

AU - Grazuleviciene, Regina

AU - Haug, Line Smastuen

AU - Hernandez-Ferrer, Carles

AU - Heude, Barbara

AU - Karachaliou, Marianna

AU - Krog, Norun Hjertager

AU - McEachan, Rosemary

AU - Nieuwenhuijsen, Mark

AU - Petraviciene, Inga

AU - Quentin, Joane

AU - Robinson, Oliver

AU - Sakhi, Amrit Kaur

AU - Slama, Remy

AU - Thomsen, Cathrine

AU - Urquiza, Jose

AU - Vafeiadi, Marina

AU - West, Jane

AU - Wright, John

AU - Vrijheid, Martine

AU - Basagana, Xavier

N1 - Funding Information: ISGlobal is a member of the Agency for the Research Centres of Catalonia (CERCA) Programme, Generalitat de Catalunya. The authors are grateful to all of the participating children, parents, practitioners, and researchers in the 6 countries who took part in this study. The authors further thank Muireann Coen, Sonia Brishoual, Angelique Serre, Michele Grosdenier, Prof. Frederic Millot, Elodie Migault, Manuela Boue, Sandy Bertin, Veronique Ferrand-Rigalleau, Céline Leger, Noella Gorry, Silvia Fochs, Nuria Pey, Cecilia Persavente, Susana Gross, Georgia Chalkiadaki, Danai Feida, Eirini Michalaki, Mariza Kampouri, Anny Kyriklaki, Minas Iakovidis, Maria Fasoulaki, Ingvild Essen, Heidi Marie Nordheim, and the Yorkshire Water. Publisher Copyright: © 2019 American College of Cardiology Foundation

PY - 2019/9/10

Y1 - 2019/9/10

N2 - BACKGROUND Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously.OBJECTIVES This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children.METHODS Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously.RESULTS Decreases in systolic BP were observed with facility density (beta change for an interquartile-range increase in exposure: -1.7 mm Hg [95% confidence interval (CI): -2.5 to -0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (-1.4 mm Hg [95% CI: -2.6 to -0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: -1.6 mm Hg [95% CI: -2.4 to -0.7 mm Hg]), hexachlorobenzene (-1.5 mm Hg [95% CI: -2.4 to -0.6 mm Hg]), and mono -benzyl phthalate (-0.7 mm Hg [95% CI: -1.3 to -0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examination (-1.4 mm Hg [95% CI: -2.3 to -0.5 mm Hg]) and child DDE concentrations (-1.1 mm Hg [95% CI: -1.9 to -0.3 mm Hg]), whereas increases in diastolic BP were observed with maternal bisphenol-A concentrations (0.7 mm Hg [95% CI: 0.1 to 1.4 mm Hg]), high fish intake during pregnancy (1.2 mm Hg [95% CI: -0.2 to 2.7 mm Hg]), and child copper concentrations (0.9 mm Hg [95% CI: 0.3 to 1.6 mm Hg]).CONCLUSIONS This study suggests that early-life exposure to several chemicals, as well as built environment and meteorological factors, may affect BP in children. (C) 2019 by the American College of Cardiology Foundation.

AB - BACKGROUND Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously.OBJECTIVES This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children.METHODS Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously.RESULTS Decreases in systolic BP were observed with facility density (beta change for an interquartile-range increase in exposure: -1.7 mm Hg [95% confidence interval (CI): -2.5 to -0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (-1.4 mm Hg [95% CI: -2.6 to -0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: -1.6 mm Hg [95% CI: -2.4 to -0.7 mm Hg]), hexachlorobenzene (-1.5 mm Hg [95% CI: -2.4 to -0.6 mm Hg]), and mono -benzyl phthalate (-0.7 mm Hg [95% CI: -1.3 to -0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examination (-1.4 mm Hg [95% CI: -2.3 to -0.5 mm Hg]) and child DDE concentrations (-1.1 mm Hg [95% CI: -1.9 to -0.3 mm Hg]), whereas increases in diastolic BP were observed with maternal bisphenol-A concentrations (0.7 mm Hg [95% CI: 0.1 to 1.4 mm Hg]), high fish intake during pregnancy (1.2 mm Hg [95% CI: -0.2 to 2.7 mm Hg]), and child copper concentrations (0.9 mm Hg [95% CI: 0.3 to 1.6 mm Hg]).CONCLUSIONS This study suggests that early-life exposure to several chemicals, as well as built environment and meteorological factors, may affect BP in children. (C) 2019 by the American College of Cardiology Foundation.

KW - blood pressure

KW - chemicals

KW - children

KW - cohort

KW - environment

KW - epidemiology

KW - exposome

KW - PERSISTENT ORGANIC POLLUTANTS

KW - CARDIOMETABOLIC TRAITS

KW - BISPHENOL-A

KW - IN-UTERO

KW - ASSOCIATION

KW - EXPOSOME

KW - CHILDHOOD

KW - MOTHER

KW - ADOLESCENTS

KW - OBESITY

U2 - 10.1016/j.jacc.2019.06.069

DO - 10.1016/j.jacc.2019.06.069

M3 - Article

C2 - 31488269

SN - 0735-1097

VL - 74

SP - 1317

EP - 1328

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 10

ER -

Early-Life Environmental Exposures and Blood Pressure in Children

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