TY - JOUR
T1 - Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer
AU - Op den Kamp, C.M.H.
AU - de Ruysscher, D.K.M.
AU - van den Heuvel, M.
AU - Elferink, M.
AU - Houben, R.M.A.
AU - Oberije, C.J.G.
AU - Bootsma, G.P.
AU - Geraedts, W.H.
AU - Pitz, C.C.M.
AU - Langen, R.C.
AU - Wouters, E.F.M.
AU - Schols, A.M.W.J.
AU - Dingemans, A.M.C.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - BACKGROUND AND PURPOSE: Radiation-esophagitis and weight loss are observed toxicities in patients treated with concurrent chemo- (CT-RT) for non-small cell lung cancer (NSCLC) and might be related. The was to investigate whether weight loss already starts early after CT-RT and precedes radiation-esophagitis. MATERIALS AND METHODS: In a retrospective cohort, weight and esophagitis grade >/=2 were assessed first weeks of (CT-)RT in patients treated with concurrent (n = 102) or sequential (n = 92) therapy. In a prospective validation study, data on weight, esophagitis grade >/=2, nutritional intake and muscle strength obtained before, during and following CT-RT. RESULTS: In the cohort, early weight loss was observed in concurrently treated patients 0.002), independent of esophagitis >/= grade 2. Early weight loss was observed in the prospective cohort (p = 0.003) and was not accompanied decreases in nutritional intake. In addition lower limb muscle strength declined (p = 0.042). In the later weeks of treatment, further body occurred (p < 0.001) despite increased nutritional supplementation and weight was only partly recovered after 4 weeks post CT-RT (p = 0.003). CONCLUSIONS: Weight loss during concurrent CT-RT for NSCLC starts early to onset of esophagitis, requiring timely and intense nutritional
AB - BACKGROUND AND PURPOSE: Radiation-esophagitis and weight loss are observed toxicities in patients treated with concurrent chemo- (CT-RT) for non-small cell lung cancer (NSCLC) and might be related. The was to investigate whether weight loss already starts early after CT-RT and precedes radiation-esophagitis. MATERIALS AND METHODS: In a retrospective cohort, weight and esophagitis grade >/=2 were assessed first weeks of (CT-)RT in patients treated with concurrent (n = 102) or sequential (n = 92) therapy. In a prospective validation study, data on weight, esophagitis grade >/=2, nutritional intake and muscle strength obtained before, during and following CT-RT. RESULTS: In the cohort, early weight loss was observed in concurrently treated patients 0.002), independent of esophagitis >/= grade 2. Early weight loss was observed in the prospective cohort (p = 0.003) and was not accompanied decreases in nutritional intake. In addition lower limb muscle strength declined (p = 0.042). In the later weeks of treatment, further body occurred (p < 0.001) despite increased nutritional supplementation and weight was only partly recovered after 4 weeks post CT-RT (p = 0.003). CONCLUSIONS: Weight loss during concurrent CT-RT for NSCLC starts early to onset of esophagitis, requiring timely and intense nutritional
U2 - 10.1007/s13539-013-0127-5
DO - 10.1007/s13539-013-0127-5
M3 - Article
C2 - 24452446
SN - 2190-5991
VL - 5
SP - 127
EP - 137
JO - Journal of cachexia, sarcopenia and muscle
JF - Journal of cachexia, sarcopenia and muscle
IS - 2
ER -