Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial

ARTIS Investigators, Martin Prins

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141 Citations (Web of Science)

Abstract

Background thrombolysis with intravenous alteplase is the only approved treatment for acute ischaemic stroke. After alteplase-induced recanalisation, reocclusion occurs in 14–34% of patients, probably because of platelet activation. Early administration of antiplatelet therapy after alteplase could reduce the risk of reocclusion and improve outcome. We compared the effects of early addition of intravenous aspirin to alteplase with standard alteplase without aspirin.
Original languageEnglish
Pages (from-to)731-737
JournalLancet
Volume380
Issue number9843
DOIs
Publication statusPublished - 25 Aug 2012

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