Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial

ARTIS Investigators, Martin Prins

Research output: Contribution to journalArticleAcademicpeer-review

141 Citations (Web of Science)


Background thrombolysis with intravenous alteplase is the only approved treatment for acute ischaemic stroke. After alteplase-induced recanalisation, reocclusion occurs in 14–34% of patients, probably because of platelet activation. Early administration of antiplatelet therapy after alteplase could reduce the risk of reocclusion and improve outcome. We compared the effects of early addition of intravenous aspirin to alteplase with standard alteplase without aspirin.
Original languageEnglish
Pages (from-to)731-737
Issue number9843
Publication statusPublished - 25 Aug 2012

Cite this