Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial

ARTIS Investigators; Martin Prins

doi:10.1016/S0140-6736(12)60949-0

Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial

ARTIS Investigators, Martin Prins

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background thrombolysis with intravenous alteplase is the only approved treatment for acute ischaemic stroke. After alteplase-induced recanalisation, reocclusion occurs in 14–34% of patients, probably because of platelet activation. Early administration of antiplatelet therapy after alteplase could reduce the risk of reocclusion and improve outcome. We compared the effects of early addition of intravenous aspirin to alteplase with standard alteplase without aspirin.

Original language	English
Pages (from-to)	731-737
Journal	Lancet
Volume	380
Issue number	9843
DOIs	https://doi.org/10.1016/S0140-6736(12)60949-0
Publication status	Published - 25 Aug 2012

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10.1016/S0140-6736(12)60949-0

Cite this

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title = "Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial",

abstract = "Background thrombolysis with intravenous alteplase is the only approved treatment for acute ischaemic stroke. After alteplase-induced recanalisation, reocclusion occurs in 14–34% of patients, probably because of platelet activation. Early administration of antiplatelet therapy after alteplase could reduce the risk of reocclusion and improve outcome. We compared the effects of early addition of intravenous aspirin to alteplase with standard alteplase without aspirin.",

author = "Zinkstok, {Sanne M.} and {ARTIS Investigators} and Martin Prins and Roos, {Yvo B. W. E. M.}",

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T1 - Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial

AU - Zinkstok, Sanne M.

AU - ARTIS Investigators

AU - Prins, Martin

AU - Roos, Yvo B. W. E. M.

PY - 2012/8/25

Y1 - 2012/8/25

N2 - Background thrombolysis with intravenous alteplase is the only approved treatment for acute ischaemic stroke. After alteplase-induced recanalisation, reocclusion occurs in 14–34% of patients, probably because of platelet activation. Early administration of antiplatelet therapy after alteplase could reduce the risk of reocclusion and improve outcome. We compared the effects of early addition of intravenous aspirin to alteplase with standard alteplase without aspirin.

AB - Background thrombolysis with intravenous alteplase is the only approved treatment for acute ischaemic stroke. After alteplase-induced recanalisation, reocclusion occurs in 14–34% of patients, probably because of platelet activation. Early administration of antiplatelet therapy after alteplase could reduce the risk of reocclusion and improve outcome. We compared the effects of early addition of intravenous aspirin to alteplase with standard alteplase without aspirin.

U2 - 10.1016/S0140-6736(12)60949-0

DO - 10.1016/S0140-6736(12)60949-0

M3 - Article

SN - 0140-6736

VL - 380

SP - 731

EP - 737

JO - Lancet

JF - Lancet

IS - 9843

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