Dysfunction at the motor end-plate and axon membrane in Guillain-Barre syndrome: a single-fiber EMG study

F. Spaans, J.W. Vredeveld, H.H. Morre, B.C. Jacobs, M.H.V. de Baets

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Dysfunction at the motor end-plate and axon membrane in Guillain-Barre syndrome: a single-fiber EMG study.

Spaans F, Vredeveld JW, Morre HH, Jacobs BC, De Baets MH.

Department of Clinical Neurophysiology, University Hospital, Postbox 5800, 6202 AZ Maastricht, The Netherlands. fsp@fknf.azm.nl

In nine patients with Guillain-Barre syndrome (GBS), stimulation single-fiber electromyography (SFEMG) and serological studies were performed in the acute stage of the illness. Increased jitter and intermittent blocking of muscle fiber action potentials occurred to a varying degree in all patients. Five patients had elevated titers of antiganglioside antibodies. The most remarkable EMG phenomenon was the occurrence in all patients of impulse blocking at normal or slightly increased jitter. The assumption that this phenomenon was due to an axolemmal dysfunction was confirmed by the occurrence in two patients of concomitant blocking of two muscle fiber action potentials at strictly normal jitter values. In one patient this sign of axonal dysfunction was demonstrated with SFEMG at voluntary activation. In another patient, concomitant blocking was associated with greatly increased but completely independent jitter of both components. The results of this study show that both a disorder of neuromuscular transmission and an axolemmal dysfunction play a role in the pathophysiology of GBS
Original languageEnglish
Pages (from-to)426-434
Number of pages8
JournalMuscle & Nerve
Volume27
Issue number4
DOIs
Publication statusPublished - 1 Jan 2003

Cite this

Spaans, F., Vredeveld, J. W., Morre, H. H., Jacobs, B. C., & de Baets, M. H. V. (2003). Dysfunction at the motor end-plate and axon membrane in Guillain-Barre syndrome: a single-fiber EMG study. Muscle & Nerve, 27(4), 426-434. https://doi.org/10.1002/mus.10334