Abstract
To assess the effect of a shrinking rectal balloon implant (RBI) on the anorectal dose and complication risk during the course of moderately hypofractionated prostate radiotherapy. In 15 patients with localized prostate cancer, an RBI was implanted. A weekly kilovolt cone-beam computed tomography (CBCT) scan was acquired to measure the dynamics of RBI volume and prostate-rectum separation. The absolute anorectal volume encompassed by the 2 Gy equieffective 75 Gy isodose (V-75Gy) was recalculated as well as the mean anorectal dose. The increase in estimated risk of grade 2-3 late rectal bleeding (LRB) between the start and end of treatment was predicted using nomograms. The observed acute and late toxicities were evaluated. A significant shrinkage of RBI volumes was observed, with an average volume of 70.4% of baseline at the end of the treatment. Although the prostate-rectum separation significantly decreased over time, it remained at least 1 cm. No significant increase in V-75Gy of the anorectum was observed, except in one patient whose RBI had completely deflated in the third week of treatment. No correlation between mean anorectal dose and balloon deflation was found. The increase in predicted LRB risk was not significant, except in the one patient whose RBI completely deflated. The observed toxicities confirmed these findings. Despite significant decrease in RBI volume the high-dose rectal volume and the predicted LRB risk were unaffected due to a persistent spacing between the prostate and the anterior rectal wall.
Original language | English |
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Pages (from-to) | 31-40 |
Number of pages | 10 |
Journal | Strahlentherapie Und onkologie |
Volume | 194 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2018 |
Keywords
- Volumetric modulated arc therapy
- Radiotherapy
- Rectum
- Volume stability
- Toxicity
- MODULATED RADIATION-THERAPY
- POLYETHYLENE-GLYCOL HYDROGEL
- EXTERNAL-BEAM RADIOTHERAPY
- CANCER PATIENTS
- SPACER APPLICATION
- ESCALATION TRIAL
- TOXICITY
- MULTICENTER
- INJECTION
- BRACHYTHERAPY