TY - JOUR
T1 - Dynamic Bioinks to Advance Bioprinting
AU - Morgan, Francis L. C.
AU - Moroni, Lorenzo
AU - Baker, Matthew B.
N1 - Funding Information:
The authors would like to acknowledge NWO for funding via the project “DynAM” under project agreement 731.016.202. M.B.B. and L.M. would also like to acknowledge the Province of Limburg for support and funding. Lastly, all authors would like to thank the community around bioink development for their feedback, discussions, and criticisims as we join to move the field forward.
Publisher Copyright:
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/8
Y1 - 2020/8
N2 - The development of bioinks for bioprinting of cell-laden constructs remains a challenge for tissue engineering, despite vigorous investigation. Hydrogels to be used as bioinks must fulfill a demanding list of requirements, mainly focused around printability and cell function. Recent advances in the use of supramolecular and dynamic covalent chemistry (DCvC) provide paths forward to develop bioinks. These dynamic hydrogels enable tailorability, higher printing performance, and the creation of more life-like environments for ultimate tissue maturation. This review focuses on the exploration and benefits of dynamically cross-linked bioinks for bioprinting, highlighting recent advances, benefits, and challenges in this emerging area. By incorporating internal dynamics, many benefits can be imparted to the material, providing design elements for next generation bioinks.
AB - The development of bioinks for bioprinting of cell-laden constructs remains a challenge for tissue engineering, despite vigorous investigation. Hydrogels to be used as bioinks must fulfill a demanding list of requirements, mainly focused around printability and cell function. Recent advances in the use of supramolecular and dynamic covalent chemistry (DCvC) provide paths forward to develop bioinks. These dynamic hydrogels enable tailorability, higher printing performance, and the creation of more life-like environments for ultimate tissue maturation. This review focuses on the exploration and benefits of dynamically cross-linked bioinks for bioprinting, highlighting recent advances, benefits, and challenges in this emerging area. By incorporating internal dynamics, many benefits can be imparted to the material, providing design elements for next generation bioinks.
KW - BIOMATERIALS
KW - COVALENT CHEMISTRY
KW - DOUBLE-NETWORK HYDROGELS
KW - EXTRACELLULAR-MATRIX
KW - GLUCOSE-RESPONSIVE HYDROGELS
KW - RATIONAL DESIGN
KW - SCAFFOLDS
KW - SHEAR-THINNING HYDROGELS
KW - SUPRAMOLECULAR POLYMERS
KW - TISSUE
KW - bioinks
KW - bioprinting
KW - dynamic hydrogels
KW - tissue engineering
KW - CELL
U2 - 10.1002/adhm.201901798
DO - 10.1002/adhm.201901798
M3 - (Systematic) Review article
C2 - 32100963
SN - 2192-2640
VL - 9
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 15
M1 - 1901798
ER -