Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

SWITCH Research Group

doi:10.1093/cid/ciac495

Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

SWITCH Research Group

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

Original language	English
Pages (from-to)	e533-e536
Journal	Clinical Infectious Diseases
Volume	76
Issue number	3
DOIs	https://doi.org/10.1093/cid/ciac495
Publication status	Published - 8 Feb 2023

Keywords

Humans
Ad26COVS1
COVID-19
SARS-CoV-2
Antibodies, Neutralizing
Antibodies, Viral
Health Personnel
Immunity

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10.1093/cid/ciac495

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title = "Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers",

abstract = "The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.",

keywords = "Humans, Ad26COVS1, COVID-19, SARS-CoV-2, Antibodies, Neutralizing, Antibodies, Viral, Health Personnel, Immunity",

author = "Sablerolles, \{Roos S G\} and Rietdijk, \{Wim J R\} and Abraham Goorhuis and Postma, \{Douwe F\} and Visser, \{Leo G\} and Schmitz, \{Katharina S\} and Daryl Geers and Susanne Bogers and \{van Haren\}, Eva and Koopmans, \{Marion P G\} and Dalm, \{Virgil A S H\} and Kootstra, \{Neeltje A\} and Huckriede, \{Anke L W\} and Renate Akkerman and Martin Beukema and Melvin Lafeber and \{van Baarle\}, Debbie and \{de Vries\}, \{Rory D\} and \{van der Kuy\}, \{P Hugo M\} and GeurtsvanKessel, \{Corine H\} and \{SWITCH Research Group\}",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2023",

month = feb,

day = "8",

doi = "10.1093/cid/ciac495",

language = "English",

volume = "76",

pages = "e533--e536",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

AU - Sablerolles, Roos S G

AU - Rietdijk, Wim J R

AU - Goorhuis, Abraham

AU - Postma, Douwe F

AU - Visser, Leo G

AU - Schmitz, Katharina S

AU - Geers, Daryl

AU - Bogers, Susanne

AU - van Haren, Eva

AU - Koopmans, Marion P G

AU - Dalm, Virgil A S H

AU - Kootstra, Neeltje A

AU - Huckriede, Anke L W

AU - Akkerman, Renate

AU - Beukema, Martin

AU - Lafeber, Melvin

AU - van Baarle, Debbie

AU - de Vries, Rory D

AU - van der Kuy, P Hugo M

AU - GeurtsvanKessel, Corine H

AU - SWITCH Research Group

PY - 2023/2/8

Y1 - 2023/2/8

N2 - The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

AB - The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

KW - Humans

KW - Ad26COVS1

KW - COVID-19

KW - SARS-CoV-2

KW - Antibodies, Neutralizing

KW - Antibodies, Viral

KW - Health Personnel

KW - Immunity

U2 - 10.1093/cid/ciac495

DO - 10.1093/cid/ciac495

M3 - Article

C2 - 35723273

SN - 1058-4838

VL - 76

SP - e533-e536

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 3

ER -

Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

Abstract

Keywords

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