Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

Elena Musat; Erik Roelofs; Raquel Bar-Deroma; Paul A. Fenton; Akos Gulyban; Laurence Collette; Roger Stupp; Damien C. Weber; J. Bernard Davis; Edwin Aird; Brigitta G. Baumert

doi:10.1016/j.radonc.2010.03.005

Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

Elena Musat^*, Erik Roelofs, Raquel Bar-Deroma, Paul A. Fenton, Akos Gulyban, Laurence Collette, Roger Stupp, Damien C. Weber, J. Bernard Davis, Edwin Aird, Brigitta G. Baumert

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas.RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF x CF); dose homogeneity in PTV (U).Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV(Dmin), improving CF. U correlated with PTV(Dmax).Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.

Original language	English
Pages (from-to)	218-224
Journal	Radiotherapy and Oncology
Volume	95
Issue number	2
DOIs	https://doi.org/10.1016/j.radonc.2010.03.005
Publication status	Published - May 2010

Keywords

Conformal radiotherapy
Dummy run
Conformity indices
Low-grade gliomas
Homogeneity
Quality assurance

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10.1016/j.radonc.2010.03.005

Cite this

Musat, E., Roelofs, E., Bar-Deroma, R., Fenton, P. A., Gulyban, A., Collette, L., Stupp, R., Weber, D. C., Davis, J. B., Aird, E., & Baumert, B. G. (2010). Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning. Radiotherapy and Oncology, 95(2), 218-224. https://doi.org/10.1016/j.radonc.2010.03.005

@article{2d5734c1a34f4f5d9d533eb59b88f012,

title = "Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning",

abstract = "Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas.RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF x CF); dose homogeneity in PTV (U).Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV(Dmin), improving CF. U correlated with PTV(Dmax).Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.",

keywords = "Conformal radiotherapy, Dummy run, Conformity indices, Low-grade gliomas, Homogeneity, Quality assurance",

author = "Elena Musat and Erik Roelofs and Raquel Bar-Deroma and Fenton, {Paul A.} and Akos Gulyban and Laurence Collette and Roger Stupp and Weber, {Damien C.} and Davis, {J. Bernard} and Edwin Aird and Baumert, {Brigitta G.}",

year = "2010",

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doi = "10.1016/j.radonc.2010.03.005",

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volume = "95",

pages = "218--224",

journal = "Radiotherapy and Oncology",

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Musat, E, Roelofs, E, Bar-Deroma, R, Fenton, PA, Gulyban, A, Collette, L, Stupp, R, Weber, DC, Davis, JB, Aird, E & Baumert, BG 2010, 'Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning', Radiotherapy and Oncology, vol. 95, no. 2, pp. 218-224. https://doi.org/10.1016/j.radonc.2010.03.005

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T1 - Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

AU - Musat, Elena

AU - Roelofs, Erik

AU - Bar-Deroma, Raquel

AU - Fenton, Paul A.

AU - Gulyban, Akos

AU - Collette, Laurence

AU - Stupp, Roger

AU - Weber, Damien C.

AU - Davis, J. Bernard

AU - Aird, Edwin

AU - Baumert, Brigitta G.

PY - 2010/5

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N2 - Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas.RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF x CF); dose homogeneity in PTV (U).Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV(Dmin), improving CF. U correlated with PTV(Dmax).Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.

AB - Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas.RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF x CF); dose homogeneity in PTV (U).Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV(Dmin), improving CF. U correlated with PTV(Dmax).Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.

KW - Conformal radiotherapy

KW - Dummy run

KW - Conformity indices

KW - Low-grade gliomas

KW - Homogeneity

KW - Quality assurance

U2 - 10.1016/j.radonc.2010.03.005

DO - 10.1016/j.radonc.2010.03.005

M3 - Article

C2 - 20378192

SN - 0167-8140

VL - 95

SP - 218

EP - 224

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 2

ER -