Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA

F.T. Peters; N. Samyn; C.T.J. Lamers; W.J. Riedel; T. Kraemer; G.D. Boeck; H.H. Maurer

doi:10.1373/clinchem.2005.052746

Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA

F.T. Peters, N. Samyn, C.T.J. Lamers, W.J. Riedel, T. Kraemer, G.D. Boeck, H.H. Maurer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: The enantiomers of the designer drugs 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) differ in their pharmacologic and toxicologic potency. The aim of this study was to develop an assay for measuring these enantiomers in small plasma volumes and to analyze samples from a controlled study with MDMA. Methods: The analytes were extracted from 1.0 and increased over time. Concentrations of S-(+)-MDA exceeded those of R-(-).-MDA, their ratios (R vs S) also increasing over time but remaining <1.0. Conclusions: This assay enables sensitive, reliable, and fast enantioselective measurement of MDA, MDMA, and MDEA in small volumes of plasma. The controlled study data confirm previous findings of MDMA and MDA enantiomer ratios (R vs S) increasing over time after ingestion of racemic MDMA.

Original language	English
Pages (from-to)	1811-1822
Journal	Clinical Chemistry
Volume	51
Issue number	10
DOIs	https://doi.org/10.1373/clinchem.2005.052746
Publication status	Published - 1 Jan 2005

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Peters, F. T., Samyn, N., Lamers, C. T. J., Riedel, W. J., Kraemer, T., Boeck, G. D., & Maurer, H. H. (2005). Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA. Clinical Chemistry, 51(10), 1811-1822. https://doi.org/10.1373/clinchem.2005.052746

Peters, F.T. ; Samyn, N. ; Lamers, C.T.J. et al. / Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA. In: Clinical Chemistry. 2005 ; Vol. 51, No. 10. pp. 1811-1822.

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title = "Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA",

abstract = "Background: The enantiomers of the designer drugs 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) differ in their pharmacologic and toxicologic potency. The aim of this study was to develop an assay for measuring these enantiomers in small plasma volumes and to analyze samples from a controlled study with MDMA. Methods: The analytes were extracted from 1.0 and increased over time. Concentrations of S-(+)-MDA exceeded those of R-(-).-MDA, their ratios (R vs S) also increasing over time but remaining <1.0. Conclusions: This assay enables sensitive, reliable, and fast enantioselective measurement of MDA, MDMA, and MDEA in small volumes of plasma. The controlled study data confirm previous findings of MDMA and MDA enantiomer ratios (R vs S) increasing over time after ingestion of racemic MDMA. ",

author = "F.T. Peters and N. Samyn and C.T.J. Lamers and W.J. Riedel and T. Kraemer and G.D. Boeck and H.H. Maurer",

year = "2005",

month = jan,

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doi = "10.1373/clinchem.2005.052746",

language = "English",

volume = "51",

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Peters, FT, Samyn, N, Lamers, CTJ, Riedel, WJ, Kraemer, T, Boeck, GD & Maurer, HH 2005, 'Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA', Clinical Chemistry, vol. 51, no. 10, pp. 1811-1822. https://doi.org/10.1373/clinchem.2005.052746

Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA. / Peters, F.T.; Samyn, N.; Lamers, C.T.J. et al.
In: Clinical Chemistry, Vol. 51, No. 10, 01.01.2005, p. 1811-1822.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA

AU - Peters, F.T.

AU - Samyn, N.

AU - Lamers, C.T.J.

AU - Riedel, W.J.

AU - Kraemer, T.

AU - Boeck, G.D.

AU - Maurer, H.H.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Background: The enantiomers of the designer drugs 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) differ in their pharmacologic and toxicologic potency. The aim of this study was to develop an assay for measuring these enantiomers in small plasma volumes and to analyze samples from a controlled study with MDMA. Methods: The analytes were extracted from 1.0 and increased over time. Concentrations of S-(+)-MDA exceeded those of R-(-).-MDA, their ratios (R vs S) also increasing over time but remaining <1.0. Conclusions: This assay enables sensitive, reliable, and fast enantioselective measurement of MDA, MDMA, and MDEA in small volumes of plasma. The controlled study data confirm previous findings of MDMA and MDA enantiomer ratios (R vs S) increasing over time after ingestion of racemic MDMA.

AB - Background: The enantiomers of the designer drugs 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) differ in their pharmacologic and toxicologic potency. The aim of this study was to develop an assay for measuring these enantiomers in small plasma volumes and to analyze samples from a controlled study with MDMA. Methods: The analytes were extracted from 1.0 and increased over time. Concentrations of S-(+)-MDA exceeded those of R-(-).-MDA, their ratios (R vs S) also increasing over time but remaining <1.0. Conclusions: This assay enables sensitive, reliable, and fast enantioselective measurement of MDA, MDMA, and MDEA in small volumes of plasma. The controlled study data confirm previous findings of MDMA and MDA enantiomer ratios (R vs S) increasing over time after ingestion of racemic MDMA.

U2 - 10.1373/clinchem.2005.052746

DO - 10.1373/clinchem.2005.052746

M3 - Article

SN - 0009-9147

VL - 51

SP - 1811

EP - 1822

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 10

ER -

Peters FT, Samyn N, Lamers CTJ, Riedel WJ, Kraemer T, Boeck GD et al. Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic-Mass Spectrometric Assay for Enantioselective Determination of the Designer Drugs MDA, MDMA (Ecstasy) and MDEA and Its Application to Samples From a Controlled Study with MDMA. Clinical Chemistry. 2005 Jan 1;51(10):1811-1822. doi: 10.1373/clinchem.2005.052746