Drug-induced interstitial lung disease: role of pharmacogenetics in predicting cytotoxic mechanisms and risks of side effects

Naomi T. Jessurun, Marjolein Drent, Eugene P. van Puijenbroek, Otto Bekers, Petal A. Wijnen, Aalt Bast*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Original languageEnglish
Pages (from-to)468-477
Number of pages10
JournalCurrent Opinion in Pulmonary Medicine
Volume25
Issue number5
DOIs
Publication statusPublished - Sep 2019

Keywords

  • adverse drug reactions
  • cytochrome P450
  • cytotoxic mechanisms
  • drug metabolizing enzymes
  • drug-induced pneumonitis
  • glucose-6-phosphate dehydrogenase
  • polymorphisms
  • thiopurine S-methyltransferase
  • xenobiotics
  • THIOPURINE METHYLTRANSFERASE
  • GENETIC-POLYMORPHISM
  • ACETAMINOPHEN
  • METABOLISM
  • INJURY
  • BIOACTIVATION
  • 4-IPOMEANOL
  • OXIDATION
  • TOXICITY
  • PROTEINS

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