Driving Performance of Depressed Patients who are Untreated or Receive Long-Term Antidepressant (SSRI/SNRI) Treatment

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction Depression is a mental disorder likely to affect everyday functions. The present study aimed to assess actual driving performance of depressed patients who were without specific antidepressant treatment or received long-term antidepressant treatment. Methods A standardized on-the-road driving test was used to assess standard deviation of lateral position (SDLP) in 3 patient groups receiving either no antidepressant treatment (with or without benzodiazepine medication) or treatment with selective serotonin/noradrenalin reuptake inhibitors for a period of 6-52 weeks. Severity of depression was assessed using Beck's Depression Inventory and the Hamilton Depression Rating Scale. The performance of patient groups was compared to healthy controls. Results The mean SDLP of untreated and treated patients was significantly higher than that of healthy controls. Driving impairment in the long-term treated group was significantly less than in the untreated groups. SDLP was positively correlated to severity of depression across all groups. Discussion It is concluded that symptoms of depression are a major cause of driving impairment. Reductions in severity of depression through antidepressant treatment reduce severity of driving impairment.

Original languageEnglish
Pages (from-to)182-188
Number of pages7
JournalPharmacopsychiatry
Volume50
Issue number5
Early online date3 Jul 2017
DOIs
Publication statusPublished - Sep 2017

Keywords

  • Journal Article
  • long-term treatment
  • OUTPATIENTS
  • antidepressants
  • ROAD-TRAFFIC ACCIDENTS
  • DRIVERS
  • IMPAIRMENT
  • driving performance
  • MIRTAZAPINE
  • PSYCHOMOTOR FUNCTION
  • YOUNG
  • ALCOHOL
  • DISORDER
  • depression

Cite this

@article{4abf35f037b44215b972eff4ee5bef1b,
title = "Driving Performance of Depressed Patients who are Untreated or Receive Long-Term Antidepressant (SSRI/SNRI) Treatment",
abstract = "Introduction Depression is a mental disorder likely to affect everyday functions. The present study aimed to assess actual driving performance of depressed patients who were without specific antidepressant treatment or received long-term antidepressant treatment. Methods A standardized on-the-road driving test was used to assess standard deviation of lateral position (SDLP) in 3 patient groups receiving either no antidepressant treatment (with or without benzodiazepine medication) or treatment with selective serotonin/noradrenalin reuptake inhibitors for a period of 6-52 weeks. Severity of depression was assessed using Beck's Depression Inventory and the Hamilton Depression Rating Scale. The performance of patient groups was compared to healthy controls. Results The mean SDLP of untreated and treated patients was significantly higher than that of healthy controls. Driving impairment in the long-term treated group was significantly less than in the untreated groups. SDLP was positively correlated to severity of depression across all groups. Discussion It is concluded that symptoms of depression are a major cause of driving impairment. Reductions in severity of depression through antidepressant treatment reduce severity of driving impairment.",
keywords = "Journal Article, long-term treatment, OUTPATIENTS, antidepressants, ROAD-TRAFFIC ACCIDENTS, DRIVERS, IMPAIRMENT, driving performance, MIRTAZAPINE, PSYCHOMOTOR FUNCTION, YOUNG, ALCOHOL, DISORDER, depression",
author = "{van der Sluiszen}, {Nick N J J M} and Marleen Wingen and Annemiek Vermeeren and Frederick Vinckenbosch and Stefan Jongen and Ramaekers, {Johannes G}",
note = "{\circledC} Georg Thieme Verlag KG Stuttgart · New York.",
year = "2017",
month = "9",
doi = "10.1055/s-0043-111600",
language = "English",
volume = "50",
pages = "182--188",
journal = "Pharmacopsychiatry",
issn = "0176-3679",
publisher = "Georg Thieme Verlag",
number = "5",

}

TY - JOUR

T1 - Driving Performance of Depressed Patients who are Untreated or Receive Long-Term Antidepressant (SSRI/SNRI) Treatment

AU - van der Sluiszen, Nick N J J M

AU - Wingen, Marleen

AU - Vermeeren, Annemiek

AU - Vinckenbosch, Frederick

AU - Jongen, Stefan

AU - Ramaekers, Johannes G

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2017/9

Y1 - 2017/9

N2 - Introduction Depression is a mental disorder likely to affect everyday functions. The present study aimed to assess actual driving performance of depressed patients who were without specific antidepressant treatment or received long-term antidepressant treatment. Methods A standardized on-the-road driving test was used to assess standard deviation of lateral position (SDLP) in 3 patient groups receiving either no antidepressant treatment (with or without benzodiazepine medication) or treatment with selective serotonin/noradrenalin reuptake inhibitors for a period of 6-52 weeks. Severity of depression was assessed using Beck's Depression Inventory and the Hamilton Depression Rating Scale. The performance of patient groups was compared to healthy controls. Results The mean SDLP of untreated and treated patients was significantly higher than that of healthy controls. Driving impairment in the long-term treated group was significantly less than in the untreated groups. SDLP was positively correlated to severity of depression across all groups. Discussion It is concluded that symptoms of depression are a major cause of driving impairment. Reductions in severity of depression through antidepressant treatment reduce severity of driving impairment.

AB - Introduction Depression is a mental disorder likely to affect everyday functions. The present study aimed to assess actual driving performance of depressed patients who were without specific antidepressant treatment or received long-term antidepressant treatment. Methods A standardized on-the-road driving test was used to assess standard deviation of lateral position (SDLP) in 3 patient groups receiving either no antidepressant treatment (with or without benzodiazepine medication) or treatment with selective serotonin/noradrenalin reuptake inhibitors for a period of 6-52 weeks. Severity of depression was assessed using Beck's Depression Inventory and the Hamilton Depression Rating Scale. The performance of patient groups was compared to healthy controls. Results The mean SDLP of untreated and treated patients was significantly higher than that of healthy controls. Driving impairment in the long-term treated group was significantly less than in the untreated groups. SDLP was positively correlated to severity of depression across all groups. Discussion It is concluded that symptoms of depression are a major cause of driving impairment. Reductions in severity of depression through antidepressant treatment reduce severity of driving impairment.

KW - Journal Article

KW - long-term treatment

KW - OUTPATIENTS

KW - antidepressants

KW - ROAD-TRAFFIC ACCIDENTS

KW - DRIVERS

KW - IMPAIRMENT

KW - driving performance

KW - MIRTAZAPINE

KW - PSYCHOMOTOR FUNCTION

KW - YOUNG

KW - ALCOHOL

KW - DISORDER

KW - depression

U2 - 10.1055/s-0043-111600

DO - 10.1055/s-0043-111600

M3 - Article

C2 - 28672405

VL - 50

SP - 182

EP - 188

JO - Pharmacopsychiatry

JF - Pharmacopsychiatry

SN - 0176-3679

IS - 5

ER -