Driving performance and neurocognition of patients with long-term medicinal drug treatment

Research output: ThesisDoctoral ThesisInternal

462 Downloads (Pure)


The research described in this thesis was aimed at assessing the influence of long-term drug use on driving ability and neurocognition (attention, reaction time, executive functioning). The main motivation for this thesis was to investigate whether long-term use of medicines can lead to changes in the regulations regarding traffic participation. Secondly, the thesis focused on identifying factors that contribute to tolerance development with long-term medication use. The results of the studies described in this thesis show that the inhibiting influence of medicines on driving ability decreases with long-term use. Factors contributing to this decrease include a reduction in clinical symptoms, tolerance development for the undesirable effects of drugs, and duration of treatment.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Ramaekers, Jan, Supervisor
  • Vermeeren, Annemiek, Co-Supervisor
Award date9 Jul 2020
Place of PublicationMaastricht
Print ISBNs9789463759755
Publication statusPublished - 2020


  • driving ability
  • drugs
  • long-term use
  • antidepressants
  • benzodiazepines
  • hypersomnolence

Cite this