Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung

G. Kayser; A. Csanadi; S. Kakanou; A. Prasse; A. Kassem; E. Stickeler; B. Passlick; A. zur Hausen

doi:10.1038/bjc.2015.2

Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung

G. Kayser^*, A. Csanadi, S. Kakanou, A. Prasse, A. Kassem, E. Stickeler, B. Passlick, A. zur Hausen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. Material and Methods: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). Results: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P = 0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P = 0.019) and histological grading (P

Original language	English
Pages (from-to)	866-873
Journal	British Journal of Cancer
Volume	112
Issue number	5
DOIs	https://doi.org/10.1038/bjc.2015.2
Publication status	Published - 3 Mar 2015

Keywords

immunohistochemistry
metastasis
metastasis suppressor 1 (MTSS1)
non-small-cell lung cancer
survival

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10.1038/bjc.2015.2Licence: CC BY-NC-SA

Cite this

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title = "Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung",

abstract = "Background: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. Material and Methods: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). Results: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P = 0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P = 0.019) and histological grading (P",

keywords = "immunohistochemistry, metastasis, metastasis suppressor 1 (MTSS1), non-small-cell lung cancer, survival",

author = "G. Kayser and A. Csanadi and S. Kakanou and A. Prasse and A. Kassem and E. Stickeler and B. Passlick and {zur Hausen}, A.",

year = "2015",

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doi = "10.1038/bjc.2015.2",

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TY - JOUR

T1 - Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung

AU - Kayser, G.

AU - Csanadi, A.

AU - Kakanou, S.

AU - Prasse, A.

AU - Kassem, A.

AU - Stickeler, E.

AU - Passlick, B.

AU - zur Hausen, A.

PY - 2015/3/3

Y1 - 2015/3/3

N2 - Background: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. Material and Methods: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). Results: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P = 0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P = 0.019) and histological grading (P

AB - Background: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. Material and Methods: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). Results: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P = 0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P = 0.019) and histological grading (P

KW - immunohistochemistry

KW - metastasis

KW - metastasis suppressor 1 (MTSS1)

KW - non-small-cell lung cancer

KW - survival

U2 - 10.1038/bjc.2015.2

DO - 10.1038/bjc.2015.2

M3 - Article

C2 - 25625275

SN - 0007-0920

VL - 112

SP - 866

EP - 873

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

ER -