Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung

G. Kayser*, A. Csanadi, S. Kakanou, A. Prasse, A. Kassem, E. Stickeler, B. Passlick, A. zur Hausen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Web of Science)

Abstract

Background: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. Material and Methods: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). Results: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P = 0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P = 0.019) and histological grading (P
Original languageEnglish
Pages (from-to)866-873
JournalBritish Journal of Cancer
Volume112
Issue number5
DOIs
Publication statusPublished - 3 Mar 2015

Keywords

  • immunohistochemistry
  • metastasis
  • metastasis suppressor 1 (MTSS1)
  • non-small-cell lung cancer
  • survival

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