Dosimetry of preclinical and clinical case studies of 18F-radiopharmaceuticals using Positron Emission Tomography and Computed Tomography: Methods of quantification, their improvement and considerations of critical exposures

F. Bretin

Dosimetry of preclinical and clinical case studies of 18F-radiopharmaceuticals using Positron Emission Tomography and Computed Tomography: Methods of quantification, their improvement and considerations of critical exposures

F. Bretin

Research output: Thesis › Doctoral Thesis › External prepared

Abstract

Computed tomography (CT) and positron emission tomography (PET) involve ionizing radiation and are routinely used in preclinical and clinical environments. The radiation burden to animals and humans needs to be addressed.
In this thesis the radiation dosimetry of 18F-radiopharmaceuticals in humans and animals was investigated and a more ethical and economic approach to preclinical dosimetry is presented. Also the dosimetry of the microCT eXplore 120 was assessed.
Animals are exposed to significant amounts of radiation in longitudinal studies from both, PET and CT, which researchers should take into account. The studied 18F-radiopharmaceuticals were considered safe for human use from a radiation point of view.

Original language	English
Awarding Institution	Maastricht University University of Liège
Supervisors/Advisors	Shah, Nadim, Supervisor Phillips, C., Supervisor Seret, A., Supervisor, External person
Award date	7 Jan 2015
Publication status	Published - 2015

Keywords

radiation
CT
PET
radiopharmaceuticals

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title = "Dosimetry of preclinical and clinical case studies of 18F-radiopharmaceuticals using Positron Emission Tomography and Computed Tomography: Methods of quantification, their improvement and considerations of critical exposures",

abstract = "Computed tomography (CT) and positron emission tomography (PET) involve ionizing radiation and are routinely used in preclinical and clinical environments. The radiation burden to animals and humans needs to be addressed. In this thesis the radiation dosimetry of 18F-radiopharmaceuticals in humans and animals was investigated and a more ethical and economic approach to preclinical dosimetry is presented. Also the dosimetry of the microCT eXplore 120 was assessed. Animals are exposed to significant amounts of radiation in longitudinal studies from both, PET and CT, which researchers should take into account. The studied 18F-radiopharmaceuticals were considered safe for human use from a radiation point of view.",

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author = "F. Bretin",

year = "2015",

language = "English",

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TY - BOOK

T1 - Dosimetry of preclinical and clinical case studies of 18F-radiopharmaceuticals using Positron Emission Tomography and Computed Tomography: Methods of quantification, their improvement and considerations of critical exposures

AU - Bretin, F.

PY - 2015

Y1 - 2015

N2 - Computed tomography (CT) and positron emission tomography (PET) involve ionizing radiation and are routinely used in preclinical and clinical environments. The radiation burden to animals and humans needs to be addressed. In this thesis the radiation dosimetry of 18F-radiopharmaceuticals in humans and animals was investigated and a more ethical and economic approach to preclinical dosimetry is presented. Also the dosimetry of the microCT eXplore 120 was assessed. Animals are exposed to significant amounts of radiation in longitudinal studies from both, PET and CT, which researchers should take into account. The studied 18F-radiopharmaceuticals were considered safe for human use from a radiation point of view.

AB - Computed tomography (CT) and positron emission tomography (PET) involve ionizing radiation and are routinely used in preclinical and clinical environments. The radiation burden to animals and humans needs to be addressed. In this thesis the radiation dosimetry of 18F-radiopharmaceuticals in humans and animals was investigated and a more ethical and economic approach to preclinical dosimetry is presented. Also the dosimetry of the microCT eXplore 120 was assessed. Animals are exposed to significant amounts of radiation in longitudinal studies from both, PET and CT, which researchers should take into account. The studied 18F-radiopharmaceuticals were considered safe for human use from a radiation point of view.

KW - radiation

KW - CT

KW - PET

KW - radiopharmaceuticals

M3 - Doctoral Thesis

ER -