Dose-Dependent Arterial Destiffening and Inward Remodeling After Olmesartan in Hypertensives With Metabolic Syndrome

Stephane Laurent*, Vacsular Mechanism Collaboration, Coen Stehouwer, Pierre Boutouyrie

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Whether angiotensin receptor blockers can dose-dependently remodel the arterial wall during long-term treatment has been largely debated. In this phase III, multicenter, randomized, double-blind, parallel-group study, 133 subjects with hypertension and metabolic syndrome were assigned to olmesartan, either 20 mg (n=44), 40 mg (n=42), or 80 mg (n=47) once a day, according to a force titration design during a 1-year period. Office blood pressure, 24-hour blood pressure, aortic stiffness (carotid-femoral pulse wave velocity), and carotid parameters were measured at baseline, 24 weeks, and 52 weeks. Pulse wave velocity significantly decreased (P
Original languageEnglish
Pages (from-to)709–716
Issue number4
Publication statusPublished - Oct 2014


  • antihypertensive agents
  • aorta
  • arteries
  • blood pressure
  • compliance
  • hypertension
  • randomized controlled trial

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