TY - JOUR
T1 - Dose-Dependent Arterial Destiffening and Inward Remodeling After Olmesartan in Hypertensives With Metabolic Syndrome
AU - Laurent, Stephane
AU - Vacsular Mechanism Collaboration,
AU - Stehouwer, Coen
AU - Boutouyrie, Pierre
PY - 2014/10
Y1 - 2014/10
N2 - Whether angiotensin receptor blockers can dose-dependently remodel the arterial wall during long-term treatment has been largely debated. In this phase III, multicenter, randomized, double-blind, parallel-group study, 133 subjects with hypertension and metabolic syndrome were assigned to olmesartan, either 20 mg (n=44), 40 mg (n=42), or 80 mg (n=47) once a day, according to a force titration design during a 1-year period. Office blood pressure, 24-hour blood pressure, aortic stiffness (carotid-femoral pulse wave velocity), and carotid parameters were measured at baseline, 24 weeks, and 52 weeks. Pulse wave velocity significantly decreased (P
AB - Whether angiotensin receptor blockers can dose-dependently remodel the arterial wall during long-term treatment has been largely debated. In this phase III, multicenter, randomized, double-blind, parallel-group study, 133 subjects with hypertension and metabolic syndrome were assigned to olmesartan, either 20 mg (n=44), 40 mg (n=42), or 80 mg (n=47) once a day, according to a force titration design during a 1-year period. Office blood pressure, 24-hour blood pressure, aortic stiffness (carotid-femoral pulse wave velocity), and carotid parameters were measured at baseline, 24 weeks, and 52 weeks. Pulse wave velocity significantly decreased (P
KW - antihypertensive agents
KW - aorta
KW - arteries
KW - blood pressure
KW - compliance
KW - hypertension
KW - randomized controlled trial
U2 - 10.1161/HYPERTENSIONAHA.114.03282
DO - 10.1161/HYPERTENSIONAHA.114.03282
M3 - Article
C2 - 25001274
SN - 0194-911X
VL - 64
SP - 709
EP - 716
JO - Hypertension
JF - Hypertension
IS - 4
ER -