Does the Structure Matter? An External Validation and Health Economic Results Comparison of Event Simulation Approaches in Severe Obesity

Björn Schwander*, Klaus Kaier, Mickaël Hiligsmann, Silvia Evers, Mark Nuijten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives As obesity-associated events impact long-term survival, health economic (HE) modelling is commonly applied, but modelling approaches are diverse. This research aimed to compare the events simulation and the HE outcomes produced by different obesity modelling approaches. Methods An external validation, using the Swedish obesity subjects (SOS) study, of three main structural event modelling approaches was performed: (1) continuous body mass index (BMI) approach; (2) risk equation approach; and (3) categorical BMI-related approach. Outcomes evaluated were mortality, cardiovascular events, and type 2 diabetes (T2D) for both the surgery and the control arms. Concordance between modelling results and the SOS study were investigated by different state-of-the-art measurements, and categorized by the grade of deviation observed (grades 1-4 expressing mild, moderate, severe, and very severe deviations). Furthermore, the costs per quality-adjusted life-year (QALY) gained of surgery versus controls were compared. Results Overall and by study arm, the risk equation approach presented the lowest average grade of deviation (overall grade 2.50; control arm 2.25; surgery arm 2.75), followed by the continuous BMI approach (overall 3.25; control 3.50; surgery 3.00) and by the categorial BMI approach (overall 3.63; control 3.50; surgery 3.75). Considering different confidence interval limits, the costs per QALY gained were fairly comparable between all structural approaches (ranging from 2,055 pound to 6,206 pound simulating a lifetime horizon). Conclusion None of the structural approaches provided perfect external event validation, although the risk equation approach showed the lowest overall deviations. The economic outcomes resulting from the three approaches were fairly comparable.
Original languageEnglish
Pages (from-to)901-915
Number of pages15
JournalPharmacoeconomics
Volume40
Issue number9
Early online date30 Jun 2022
DOIs
Publication statusPublished - Sept 2022

Keywords

  • BODY-MASS INDEX
  • TYPE-2 DIABETES-MELLITUS
  • CORONARY HEART-DISEASE
  • COST-EFFECTIVENESS
  • OUTCOMES MODEL
  • RISK PROFILE
  • LIFE-STYLE
  • STROKE
  • UK
  • IDENTIFICATION

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