Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial

C.H. Murphy; E.M. Flanagan; G. De Vito; D. Susta; K.A.J. Mitchelson; E.D. Castro; J.M.G. Senden; J.P.B. Goessens; A. Miklosz; A. Chabowski; R. Segurado; C.A. Corish; S.N. McCarthy; B. Egan; L.J.C. van Loon; H.M. Roche

doi:10.1093/ajcn/nqaa449

Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial

C.H. Murphy, E.M. Flanagan, G. De Vito, D. Susta, K.A.J. Mitchelson, E.D. Castro, J.M.G. Senden, J.P.B. Goessens, A. Miklosz, A. Chabowski, R. Segurado, C.A. Corish, S.N. McCarthy, B. Egan, L.J.C. van Loon, H.M. Roche^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Web of Science)

Original language	English
Pages (from-to)	1411-1427
Number of pages	17
Journal	American Journal of Clinical Nutrition
Volume	113
Issue number	6
DOIs	https://doi.org/10.1093/ajcn/nqaa449
Publication status	Published - 1 Jun 2021

Keywords

aging
LC n-3 PUFA
leucine
protein
muscle mass
strength
sarcopenia
AMINO-ACID SUPPLEMENTATION
DIETARY-FAT MODIFICATION
SERUM CYSTATIN-C
HEALTHY OLDER
BODY-COMPOSITION
VITAMIN-D
RISK-FACTORS
ELDERLY-PEOPLE
EXERCISE
AGE

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Cite this

Murphy, C. H., Flanagan, E. M., De Vito, G., Susta, D., Mitchelson, K. A. J., Castro, E. D., Senden, J. M. G., Goessens, J. P. B., Miklosz, A., Chabowski, A., Segurado, R., Corish, C. A., McCarthy, S. N., Egan, B., van Loon, L. J. C., & Roche, H. M. (2021). Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition, 113(6), 1411-1427. https://doi.org/10.1093/ajcn/nqaa449

Murphy, C.H. ; Flanagan, E.M. ; De Vito, G. ; Susta, D. ; Mitchelson, K.A.J. ; Castro, E.D. ; Senden, J.M.G. ; Goessens, J.P.B. ; Miklosz, A. ; Chabowski, A. ; Segurado, R. ; Corish, C.A. ; McCarthy, S.N. ; Egan, B. ; van Loon, L.J.C. ; Roche, H.M. / Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial. In: American Journal of Clinical Nutrition. 2021 ; Vol. 113, No. 6. pp. 1411-1427.

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keywords = "aging, LC n-3 PUFA, leucine, protein, muscle mass, strength, sarcopenia, AMINO-ACID SUPPLEMENTATION, DIETARY-FAT MODIFICATION, SERUM CYSTATIN-C, HEALTHY OLDER, BODY-COMPOSITION, VITAMIN-D, RISK-FACTORS, ELDERLY-PEOPLE, EXERCISE, AGE",

author = "C.H. Murphy and E.M. Flanagan and {De Vito}, G. and D. Susta and K.A.J. Mitchelson and E.D. Castro and J.M.G. Senden and J.P.B. Goessens and A. Miklosz and A. Chabowski and R. Segurado and C.A. Corish and S.N. McCarthy and B. Egan and {van Loon}, L.J.C. and H.M. Roche",

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Murphy, CH, Flanagan, EM, De Vito, G, Susta, D, Mitchelson, KAJ, Castro, ED, Senden, JMG, Goessens, JPB, Miklosz, A, Chabowski, A, Segurado, R, Corish, CA, McCarthy, SN, Egan, B, van Loon, LJC & Roche, HM 2021, 'Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial', American Journal of Clinical Nutrition, vol. 113, no. 6, pp. 1411-1427. https://doi.org/10.1093/ajcn/nqaa449

Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial. / Murphy, C.H.; Flanagan, E.M.; De Vito, G.; Susta, D.; Mitchelson, K.A.J.; Castro, E.D.; Senden, J.M.G.; Goessens, J.P.B.; Miklosz, A.; Chabowski, A.; Segurado, R.; Corish, C.A.; McCarthy, S.N.; Egan, B.; van Loon, L.J.C.; Roche, H.M.

In: American Journal of Clinical Nutrition, Vol. 113, No. 6, 01.06.2021, p. 1411-1427.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Murphy, C.H.

AU - Flanagan, E.M.

AU - De Vito, G.

AU - Susta, D.

AU - Mitchelson, K.A.J.

AU - Castro, E.D.

AU - Senden, J.M.G.

AU - Goessens, J.P.B.

AU - Miklosz, A.

AU - Chabowski, A.

AU - Segurado, R.

AU - Corish, C.A.

AU - McCarthy, S.N.

AU - Egan, B.

AU - van Loon, L.J.C.

AU - Roche, H.M.

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KW - strength

KW - sarcopenia

KW - AMINO-ACID SUPPLEMENTATION

KW - DIETARY-FAT MODIFICATION

KW - SERUM CYSTATIN-C

KW - HEALTHY OLDER

KW - BODY-COMPOSITION

KW - VITAMIN-D

KW - RISK-FACTORS

KW - ELDERLY-PEOPLE

KW - EXERCISE

KW - AGE

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JF - American Journal of Clinical Nutrition

SN - 0002-9165

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Murphy CH, Flanagan EM, De Vito G, Susta D, Mitchelson KAJ, Castro ED et al. Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition. 2021 Jun 1;113(6):1411-1427. https://doi.org/10.1093/ajcn/nqaa449