TY - JOUR
T1 - Does parity matter in women's risk of dementia?
T2 - A COSMIC collaboration cohort study
AU - Bae, Jong Bin
AU - Lipnicki, Darren M.
AU - Han, Ji Won
AU - Sachdev, Perminder S.
AU - Kim, Tae Hui
AU - Kwak, Kyung Phil
AU - Kim, Bong Jo
AU - Kim, Shin Gyeom
AU - Kim, Jeong Lan
AU - Moon, Seok Woo
AU - Park, Joon Hyuk
AU - Ryu, Seung-Ho
AU - Youn, Jong Chul
AU - Lee, Dong Young
AU - Lee, Dong Woo
AU - Lee, Seok Bum
AU - Lee, Jung Jae
AU - Jhoo, Jin Hyeong
AU - Llibre-Rodriguez, Juan J.
AU - Llibre-Guerra, Jorge J.
AU - Valhuerdi-Cepero, Adolfo J.
AU - Ritchie, Karen
AU - Ancelin, Marie-Laure
AU - Carriere, Isabelle
AU - Skoog, Ingmar
AU - Najar, Jenna
AU - Sterner, Therese Rydberg
AU - Scarmeas, Nikolaos
AU - Yannakoulia, Mary
AU - Dardiotis, Efthimios
AU - Meguro, Kenichi
AU - Kasai, Mari
AU - Nakamura, Kei
AU - Riedel-Heller, Steffi
AU - Roehr, Susanne
AU - Pabst, Alexander
AU - van Boxtel, Martin
AU - Kohler, Sebastian
AU - Ding, Ding
AU - Zhao, Qianhua
AU - Liang, Xiaoniu
AU - Scazufca, Marcia
AU - Lobo, Antonio
AU - De-la-Camara, Concepcion
AU - Lobo, Elena
AU - Kim, Ki Woong
AU - Cohort Studies of Memory in an International Consortium (COSMIC)
PY - 2020/8/5
Y1 - 2020/8/5
N2 - Background Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied. Methods We harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype. Results Across all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10-1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR = 2.99, 95% CI = 1.38-6.47) and Latin America (OR = 1.49, 95% CI = 1.04-2.12), while nulliparous women showed a higher dementia risk in Asia (OR = 2.15, 95% CI = 1.33-3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR = 6.86, 95% CI = 1.81-26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR = 1.91, 95% CI 1.07-3.39) and non-Alzheimer non-vascular dementia (OR = 3.47, 95% CI = 1.44-8.35) in Asia. Conclusion Parity is associated with women's risk of dementia, though this is not uniform across regions and dementia subtypes.
AB - Background Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied. Methods We harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype. Results Across all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10-1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR = 2.99, 95% CI = 1.38-6.47) and Latin America (OR = 1.49, 95% CI = 1.04-2.12), while nulliparous women showed a higher dementia risk in Asia (OR = 2.15, 95% CI = 1.33-3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR = 6.86, 95% CI = 1.81-26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR = 1.91, 95% CI 1.07-3.39) and non-Alzheimer non-vascular dementia (OR = 3.47, 95% CI = 1.44-8.35) in Asia. Conclusion Parity is associated with women's risk of dementia, though this is not uniform across regions and dementia subtypes.
KW - Dementia
KW - Alzheimer's disease
KW - Risk factors
KW - Parity
KW - Women
KW - ALZHEIMERS-DISEASE
KW - PREGNANCY
KW - ESTRADIOL
KW - HEALTH
KW - ATHEROSCLEROSIS
KW - ASSOCIATION
KW - POPULATION
KW - PREVALENCE
KW - PREMATURE
KW - PROFILES
U2 - 10.1186/s12916-020-01671-1
DO - 10.1186/s12916-020-01671-1
M3 - Article
C2 - 32753059
SN - 1741-7015
VL - 18
JO - BMC Medicine
JF - BMC Medicine
IS - 1
M1 - 210
ER -