Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk

E. Kellen; M.P.A. Zeegers; A.D.C. Paulussen; R.F.M. Vlietinck; E.V. Vlem; H. Veulemans; F. Buntinx

doi:10.1016/j.canlet.2005.12.025

Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk

E. Kellen^*, M.P.A. Zeegers, A.D.C. Paulussen, R.F.M. Vlietinck, E.V. Vlem, H. Veulemans, F. Buntinx

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To investigate the association between occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines and diesel and bladder cancer risk and the modification by smoking and metabolic polymorphisms, have we recruited 200 cases and 385 population controls. The adjusted OR of bladder cancer was 5.75 (95%CI 2.09-15.83) comparing the highest tertile of the cumulative probability of occupational exposure to aromatic amines with no occupational exposure. A possible interaction between occupational exposures to aromatic amines and smoking was found. The increased ORs of GSTM1, GSTT1, NAT2 and SULT1A1 among those ever occupational exposed was explored by estimating the false-positive report probability. We confirm that occupational exposure to aromatic amines is associated with an increase in bladder cancer risk

Original language	English
Pages (from-to)	51-60
Journal	Cancer Letters
Volume	245
Issue number	1-2
DOIs	https://doi.org/10.1016/j.canlet.2005.12.025
Publication status	Published - 1 Jan 2007

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Kellen, E., Zeegers, M. P. A., Paulussen, A. D. C., Vlietinck, R. F. M., Vlem, E. V., Veulemans, H., & Buntinx, F. (2007). Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk. Cancer Letters, 245(1-2), 51-60. https://doi.org/10.1016/j.canlet.2005.12.025

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title = "Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk",

abstract = "To investigate the association between occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines and diesel and bladder cancer risk and the modification by smoking and metabolic polymorphisms, have we recruited 200 cases and 385 population controls. The adjusted OR of bladder cancer was 5.75 (95%CI 2.09-15.83) comparing the highest tertile of the cumulative probability of occupational exposure to aromatic amines with no occupational exposure. A possible interaction between occupational exposures to aromatic amines and smoking was found. The increased ORs of GSTM1, GSTT1, NAT2 and SULT1A1 among those ever occupational exposed was explored by estimating the false-positive report probability. We confirm that occupational exposure to aromatic amines is associated with an increase in bladder cancer risk",

author = "E. Kellen and M.P.A. Zeegers and A.D.C. Paulussen and R.F.M. Vlietinck and E.V. Vlem and H. Veulemans and F. Buntinx",

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Kellen, E, Zeegers, MPA , Paulussen, ADC, Vlietinck, RFM, Vlem, EV, Veulemans, H & Buntinx, F 2007, 'Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk', Cancer Letters, vol. 245, no. 1-2, pp. 51-60. https://doi.org/10.1016/j.canlet.2005.12.025

Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk. / Kellen, E.; Zeegers, M.P.A.; Paulussen, A.D.C. et al.
In: Cancer Letters, Vol. 245, No. 1-2, 01.01.2007, p. 51-60.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Vlem, E.V.

AU - Veulemans, H.

AU - Buntinx, F.

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AB - To investigate the association between occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines and diesel and bladder cancer risk and the modification by smoking and metabolic polymorphisms, have we recruited 200 cases and 385 population controls. The adjusted OR of bladder cancer was 5.75 (95%CI 2.09-15.83) comparing the highest tertile of the cumulative probability of occupational exposure to aromatic amines with no occupational exposure. A possible interaction between occupational exposures to aromatic amines and smoking was found. The increased ORs of GSTM1, GSTT1, NAT2 and SULT1A1 among those ever occupational exposed was explored by estimating the false-positive report probability. We confirm that occupational exposure to aromatic amines is associated with an increase in bladder cancer risk

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DO - 10.1016/j.canlet.2005.12.025

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Kellen E, Zeegers MPA , Paulussen ADC, Vlietinck RFM, Vlem EV, Veulemans H et al. Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk. Cancer Letters. 2007 Jan 1;245(1-2):51-60. doi: 10.1016/j.canlet.2005.12.025