Does heart-type fatty acid-binding protein predict clinical outcomes after pediatric cardiac surgery

Egmond S. Evers, Varsha Walavalkar, Suresh Pujar, Latha Balasubramanian, Frits W. Prinzen, Tammo Delhaas, Ward Y. Vanagt*, Shreesha Maiya

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Introduction: The early identification of vulnerable pediatric cardiac surgery patients can help clinicians provide them with timely support. Heart-type fatty acid-binding protein. (H-FABP) is an early biomarker of myocardial injury in acute myocardial infarction in adults. In this study, we evaluated the correlations between postoperative H-FABP, creatine kinase-myocardial band (CK-MB), troponin-I, total bypass time, and clinical outcomes. Methods: In 32 pediatric patients that underwent ventricular septal defect. closure we measured H-FABP, troponin-I and CK-MB preoperatively and 1, 3, and 6 h after aortic declamping. Spearman's Rho correlations were calculated between laboratory and clinical parameters including inotropic support duration, aortic cross-clamp time, total bypass time, ventilation.weaning.time, and total Intensive Care Unit stay. Results: H-FABP, CK-MB, troponin-I, and total bypass time have a similarly weak to moderate correlation with clinical outcome measures. Conclusions: The predictive value of H-FABP for clinical outcome is not stronger than that of CK-MB, Troponin-I, or bypass times.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalAnnals of Pediatric Cardiology
Volume10
Issue number3
DOIs
Publication statusPublished - 2017

Keywords

  • Bypass time
  • heart-type fatty acid-binding protein
  • pediatric cardiac surgery
  • MYOCARDIAL DAMAGE

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