Does glutamine-enriched parenteral nutrition really affect intestinal morphology and gut permeability?

K.W.E. Hulsewé*, B.A. van Acker, W. Hameeteman, R.R.W.J. van der Hulst, T. Vainas, J.W. Arends, B.K. van Kreel, M.F. von Meyenfeldt, P.B. Soeters

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: Nutritional depletion has been related to low glutamine levels in plasma and gut mucosa. This study was set up to investigate the effects of glutamine-enriched total parenteral nutrition on intestinal morphology and permeability. METHODS: Twenty-three depleted patients were randomized and after stabilization baseline measurements were performed. Plasma glutamine concentrations, gut morphology (including proliferation and lymphocyte markers) and intestinal permeability were measured. After administration during 8-10 days of a glutamine enriched total parenteral nutrition or an isonitrogenous control solution the measurements were repeated. RESULTS: No significant changes in glutamine concentrations, intestinal permeability, mucosal morphology or gut mucosal inflammation were observed between groups. CONCLUSIONS: Glutamine enriched total parenteral nutrition in a depleted patient population does not result in improvements in gut morphology and gut barrier function.
Original languageEnglish
Pages (from-to)1217-1225
JournalClinical Nutrition
Issue number5
Publication statusPublished - 1 Jan 2004


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