TY - JOUR
T1 - Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts
AU - Contreras, Zuelma A.
AU - Chen, Zhanghua
AU - Roumeliotaki, Theano
AU - Annesi-Maesano, Isabella
AU - Baiz, Nour
AU - von Berg, Andrea
AU - Bergstrom, Anna
AU - Crozier, Sarah
AU - Duijts, Liesbeth
AU - Ekstrom, Sandra
AU - Eller, Esben
AU - Fantini, Maria P.
AU - Kjaer, Henrik Fomsgaard
AU - Forastiere, Francesco
AU - Gerhard, Beatrix
AU - Gori, Davide
AU - Harskamp-van Ginkel, Margreet W.
AU - Heinrich, Joachim
AU - Iniguez, Carmen
AU - Inskip, Hazel
AU - Keil, Thomas
AU - Kogevinas, Manolis
AU - Lau, Susanne
AU - Lehmann, Irina
AU - Maier, Dieter
AU - van Meel, Evelien R.
AU - Mommers, Monique
AU - Murcia, Mario
AU - Porta, Daniela
AU - Smit, Henriette A.
AU - Standl, Marie
AU - Stratakis, Nikos
AU - Sunyer, Jordi
AU - Thijs, Carel
AU - Torrent, Maties
AU - Vrijkotte, Tanja G. M.
AU - Wijga, Alet H.
AU - Berhane, Kiros
AU - Gilliland, Frank
AU - Chatzi, Leda
PY - 2018/9/1
Y1 - 2018/9/1
N2 - The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.
AB - The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.
KW - BODY-MASS INDEX
KW - INCIDENT ASTHMA
KW - PROFILE
KW - CHILDREN
KW - OVERWEIGHT
KW - ALLERGY
U2 - 10.1183/13993003.00504-2018
DO - 10.1183/13993003.00504-2018
M3 - Article
SN - 0903-1936
VL - 52
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 3
M1 - 1800504
ER -