Does a Change in Bone Mineral Density Occur in the Mandible of Gottingen Minipigs After Irradiation in Correlation With Radiation Dose and Implant Surgery?

Lucas J. Poort*, Gerhard K. P. Bittermann, Roland A. Bockmann, Frank J. Hoebers, Ruud Houben, Alida A. Postma, Peter A. W. H. Kessler

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)


Purpose: To date, studies have not agreed on the effects of irradiation on bone mineral density. The aim of our study was to investigate the changes in mandibular bone mineral density after irradiation at various doses with and without surgery. Materials and Methods: We implemented a descriptive animal experiment. The sample included 16 female Gottingen Minipigs, randomly assigned to 4 groups and irradiated with equivalent doses of 0, 25, 50, and 70 Gy to the mandibular region. At 3 months after irradiation, the mandibular left premolars and molars were removed, and dental implants were placed. Computed tomography scans were taken before and 6 months after irradiation. The measured bone density was related to a bone phantom to calculate the bone mineral density quotient (BMDQ). The outcome variable was the BMDQ. Other study variables were the radiation dose and surgery. Descriptive and univariate analyses were computed, and significance was set at P
Original languageEnglish
Pages (from-to)2149-2156
JournalJournal of Oral and Maxillofacial Surgery
Issue number11
Publication statusPublished - Nov 2014

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