Do level and variability of systolic blood pressure predict arterial properties or vice versa?

Y-P Liu, Y-M Gu, L. Thijs, K. Asayama, Y. Jin, L. Jacobs, T. Kuznetsova, P. Verhamme, L. Van Bortel, H. A. J. Struijker-Boudier, J. A. Staessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


No longitudinal study addressed whether systolic blood pressure level (SBPL) or within-visit variability (SBPV) predict arterial properties or vice versa. In families randomly recruited from a Flemish population, we determined SBPL and SBPV from five consecutive blood pressure readings. The indexes of SBPV were variability independent of the mean, the difference between maximum and minimum SBPL, and average real variability. We measured carotid intima-media thickness and distensibility by ultrasound and carotid-femoral pulse wave velocity by tonometry (SphygmoCor, version 8.2). Effect sizes were computed for 1-s.d. increments in the predictors, while accounting for covariables and family clusters. Among 1087 participants (50.4% women; mean age, 41.8 years), followed up for 2.55 years (median), higher SBPL predicted (P = 0.11). In a subset of 713 participants, followed up for another 3.14 years, lower carotid distensibility predicted (P
Original languageEnglish
Pages (from-to)316-322
JournalJournal of Human Hypertension
Issue number5
Publication statusPublished - May 2014


  • arterial stiffness
  • blood pressure
  • intima-media thickness
  • population science
  • pulse wave velocity

Cite this