DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

Leonidas Chouliaras; Gunter Kenis; Pieter Jelle Visser; Philip Scheltens; Magda Tsolaki; Roy W. Jones; Patrick G. Kehoe; Caroline Graff; Nicola G. Girtler; Asa K. Wallin; Marcel Olde Rikkert; Luiza Spiru; Lyzel S. Elias-Sonnenschein; Inez H. G. B. Ramakers; Ehsan Pishva; Jim van Os; Harry W. M. Steinbusch; Frans R. J. Verhey; Daniel L. A. van den Hove; Bart P. F. Rutten

doi:10.2217/EPI.15.22

DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

Leonidas Chouliaras, Gunter Kenis, Pieter Jelle Visser, Philip Scheltens, Magda Tsolaki, Roy W. Jones, Patrick G. Kehoe, Caroline Graff, Nicola G. Girtler, Asa K. Wallin, Marcel Olde Rikkert, Luiza Spiru, Lyzel S. Elias-Sonnenschein, Inez H. G. B. Ramakers, Ehsan Pishva, Jim van Os, Harry W. M. Steinbusch, Frans R. J. Verhey, Daniel L. A. van den Hove, Bart P. F. Rutten^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Web of Science)

Abstract

Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.

Original language	English
Pages (from-to)	533-537
Journal	Epigenomics
Volume	7
Issue number	4
DOIs	https://doi.org/10.2217/EPI.15.22
Publication status	Published - 2015

Keywords

aging
DNA methylation
DNMT3A
epigenetics
MCI
mild cognitive impairment
SNP

Access to Document

10.2217/EPI.15.22

Cite this

Chouliaras, L., Kenis, G., Visser, P. J., Scheltens, P., Tsolaki, M., Jones, R. W., Kehoe, P. G., Graff, C., Girtler, N. G., Wallin, A. K., Rikkert, M. O., Spiru, L., Elias-Sonnenschein, L. S., Ramakers, I. H. G. B., Pishva, E., van Os, J., Steinbusch, H. W. M., Verhey, F. R. J., van den Hove, D. L. A., & Rutten, B. P. F. (2015). DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts. Epigenomics, 7(4), 533-537. https://doi.org/10.2217/EPI.15.22

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title = "DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts",

abstract = "Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.",

keywords = "aging, DNA methylation, DNMT3A, epigenetics, MCI, mild cognitive impairment, SNP",

author = "Leonidas Chouliaras and Gunter Kenis and Visser, {Pieter Jelle} and Philip Scheltens and Magda Tsolaki and Jones, {Roy W.} and Kehoe, {Patrick G.} and Caroline Graff and Girtler, {Nicola G.} and Wallin, {Asa K.} and Rikkert, {Marcel Olde} and Luiza Spiru and Elias-Sonnenschein, {Lyzel S.} and Ramakers, {Inez H. G. B.} and Ehsan Pishva and {van Os}, Jim and Steinbusch, {Harry W. M.} and Verhey, {Frans R. J.} and {van den Hove}, {Daniel L. A.} and Rutten, {Bart P. F.}",

year = "2015",

doi = "10.2217/EPI.15.22",

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Chouliaras, L, Kenis, G , Visser, PJ, Scheltens, P, Tsolaki, M, Jones, RW, Kehoe, PG, Graff, C, Girtler, NG, Wallin, AK, Rikkert, MO, Spiru, L, Elias-Sonnenschein, LS, Ramakers, IHGB, Pishva, E, van Os, J, Steinbusch, HWM , Verhey, FRJ , van den Hove, DLA & Rutten, BPF 2015, 'DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts', Epigenomics, vol. 7, no. 4, pp. 533-537. https://doi.org/10.2217/EPI.15.22

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AU - Chouliaras, Leonidas

AU - Kenis, Gunter

AU - Visser, Pieter Jelle

AU - Scheltens, Philip

AU - Tsolaki, Magda

AU - Jones, Roy W.

AU - Kehoe, Patrick G.

AU - Graff, Caroline

AU - Girtler, Nicola G.

AU - Wallin, Asa K.

AU - Rikkert, Marcel Olde

AU - Spiru, Luiza

AU - Elias-Sonnenschein, Lyzel S.

AU - Ramakers, Inez H. G. B.

AU - Pishva, Ehsan

AU - van Os, Jim

AU - Steinbusch, Harry W. M.

AU - Verhey, Frans R. J.

AU - van den Hove, Daniel L. A.

AU - Rutten, Bart P. F.

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KW - DNA methylation

KW - DNMT3A

KW - epigenetics

KW - MCI

KW - mild cognitive impairment

KW - SNP

U2 - 10.2217/EPI.15.22

DO - 10.2217/EPI.15.22

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