DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

Leonidas Chouliaras, Gunter Kenis, Pieter Jelle Visser, Philip Scheltens, Magda Tsolaki, Roy W. Jones, Patrick G. Kehoe, Caroline Graff, Nicola G. Girtler, Asa K. Wallin, Marcel Olde Rikkert, Luiza Spiru, Lyzel S. Elias-Sonnenschein, Inez H. G. B. Ramakers, Ehsan Pishva, Jim van Os, Harry W. M. Steinbusch, Frans R. J. Verhey, Daniel L. A. van den Hove, Bart P. F. Rutten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.
Original languageEnglish
Pages (from-to)533-537
Issue number4
Publication statusPublished - 2015


  • aging
  • DNA methylation
  • DNMT3A
  • epigenetics
  • MCI
  • mild cognitive impairment
  • SNP

Cite this