@article{5c2d26e17d7c49f3a2b7be7e111ad70f,
title = "DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases",
abstract = "We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.",
keywords = "C-Reactive Protein/genetics, CpG Islands/genetics, DNA Methylation/genetics, Humans, Inflammation/genetics, Nucleotide Motifs, C-REACTIVE PROTEIN, TRANSCRIPTION, MARKERS, GENOME, PREDICTION, LIFETIME RISK, BODY-MASS INDEX, NF-KAPPA-B, EPIGENOME-WIDE ASSOCIATION, BLOOD",
author = "Matthias Wielscher and Mandaviya, {Pooja R} and Brigitte Kuehnel and Roby Joehanes and Rima Mustafa and Oliver Robinson and Yan Zhang and Barbara Bodinier and Esther Walton and Mishra, {Pashupati P} and Pascal Schlosser and Rory Wilson and Pei-Chien Tsai and Saranya Palaniswamy and Marioni, {Riccardo E} and Giovanni Fiorito and Giovanni Cugliari and Ville Karhunen and Mohsen Ghanbari and Psaty, {Bruce M} and Marie Loh and Bis, {Joshua C} and Benjamin Lehne and Nona Sotoodehnia and Deary, {Ian J} and Marc Chadeau-Hyam and Brody, {Jennifer A} and Alexia Cardona and Elizabeth Selvin and Smith, {Alicia K} and Miller, {Andrew H} and Torres, {Mylin A} and Eirini Marouli and Xin G{\`a}o and {van Meurs}, {Joyce B J} and Johanna Graf-Schindler and Wolfgang Rathmann and Wolfgang Koenig and Annette Peters and Wolfgang Weninger and Matthias Farlik and Tao Zhang and Wei Chen and Yujing Xia and Alexander Teumer and Matthias Nauck and Grabe, {Hans J} and Macus Doerr and Terho Lehtim{\"a}ki and Weihua Guan and {BIOS Consortium} and Marjo-Riitta J{\"a}rvelin",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = may,
day = "3",
doi = "10.1038/s41467-022-29792-6",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}