DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

Panagiotis Georgiadis; Marios Gavriil; Panu Rantakokko; Efthymios Ladoukakis; Maria Botsivali; Rachel S. Kelly; Ingvar A. Bergdahl; Hannu Kiviranta; Roel C. H. Vermeulen; Florentin Spaeth; Dennie G. A. J. Hebbels; Jos C. S. Kleinjans; Theo M. C. M. de Kok; Domenico Palli; Paolo Vineis; Soterios A. Kyrtopoulos; Ralph Gottschalk; Danitsja van Leeuwen; Leen Timmermans; Benedetta Bendinelli; Lutzen Portengen; Fatemeh Saberi-Hosnijeh; Beatrice Melin; Goran Hallmans; Per Lenner; Hector C. Keun; Alexandros Siskos; Toby J. Athersuch; Manolis Kogevinas; Euripides G. Stephanou; Antonis Myridakis; Lucia Fazzo; Marco De Santis; Pietro Comba; Riikka Airaksinen; Paivi Ruokojarvi; Mark Gilthorpe; Sarah Fleming; Thomas Fleming; Yu-Kang Tu; Bo Jonsson; Thomas Lundh; Wei J. Chen; Wen-Chung Lee; Chuhsing Kate Hsiao; Kuo-Liong Chien; Po-Hsiu Kuo; Hung Hung; Shu-Fen Liao; EnviroGenomarkers Consortium

doi:10.1016/j.envint.2019.01.068

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

Panagiotis Georgiadis, Marios Gavriil, Panu Rantakokko, Efthymios Ladoukakis, Maria Botsivali, Rachel S. Kelly, Ingvar A. Bergdahl, Hannu Kiviranta, Roel C. H. Vermeulen, Florentin Spaeth, Dennie G. A. J. Hebbels, Jos C. S. Kleinjans, Theo M. C. M. de Kok, Domenico Palli, Paolo Vineis, Soterios A. Kyrtopoulos^*, Ralph Gottschalk, Danitsja van Leeuwen, Leen Timmermans, Benedetta BendinelliLutzen Portengen, Fatemeh Saberi-Hosnijeh, Beatrice Melin, Goran Hallmans, Per Lenner, Hector C. Keun, Alexandros Siskos, Toby J. Athersuch, Manolis Kogevinas, Euripides G. Stephanou, Antonis Myridakis, Lucia Fazzo, Marco De Santis, Pietro Comba, Riikka Airaksinen, Paivi Ruokojarvi, Mark Gilthorpe, Sarah Fleming, Thomas Fleming, Yu-Kang Tu, Bo Jonsson, Thomas Lundh, Wei J. Chen, Wen-Chung Lee, Chuhsing Kate Hsiao, Kuo-Liong Chien, Po-Hsiu Kuo, Hung Hung, Shu-Fen Liao, EnviroGenomarkers Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	24-36
Number of pages	13
Journal	Environment International
Volume	126
DOIs	https://doi.org/10.1016/j.envint.2019.01.068
Publication status	Published - May 2019

Keywords

Molecular epidemiology
Persistent organic pollutants
DNA methylation
B-cell lymphoma
Environmental toxicology
Hazard assessment
PERSISTENT ORGANIC POLLUTANTS
POLYCHLORINATED BIPHENYL EXPOSURES
POLYCOMB
GENES
RISK
LYMPHOMA
CANCER
ROLES
HYPERMETHYLATION
HYPOMETHYLATION

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10.1016/j.envint.2019.01.068

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Georgiadis, P., Gavriil, M., Rantakokko, P., Ladoukakis, E., Botsivali, M., Kelly, R. S., Bergdahl, I. A., Kiviranta, H., Vermeulen, R. C. H., Spaeth, F., Hebbels, D. G. A. J., Kleinjans, J. C. S., de Kok, T. M. C. M., Palli, D., Vineis, P., Kyrtopoulos, S. A., Gottschalk, R., van Leeuwen, D., Timmermans, L., ... EnviroGenomarkers Consortium (2019). DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia. Environment International, 126, 24-36. https://doi.org/10.1016/j.envint.2019.01.068

Georgiadis, Panagiotis ; Gavriil, Marios ; Rantakokko, Panu ; Ladoukakis, Efthymios ; Botsivali, Maria ; Kelly, Rachel S. ; Bergdahl, Ingvar A. ; Kiviranta, Hannu ; Vermeulen, Roel C. H. ; Spaeth, Florentin ; Hebbels, Dennie G. A. J. ; Kleinjans, Jos C. S. ; de Kok, Theo M. C. M. ; Palli, Domenico ; Vineis, Paolo ; Kyrtopoulos, Soterios A. ; Gottschalk, Ralph ; van Leeuwen, Danitsja ; Timmermans, Leen ; Bendinelli, Benedetta ; Portengen, Lutzen ; Saberi-Hosnijeh, Fatemeh ; Melin, Beatrice ; Hallmans, Goran ; Lenner, Per ; Keun, Hector C. ; Siskos, Alexandros ; Athersuch, Toby J. ; Kogevinas, Manolis ; Stephanou, Euripides G. ; Myridakis, Antonis ; Fazzo, Lucia ; De Santis, Marco ; Comba, Pietro ; Airaksinen, Riikka ; Ruokojarvi, Paivi ; Gilthorpe, Mark ; Fleming, Sarah ; Fleming, Thomas ; Tu, Yu-Kang ; Jonsson, Bo ; Lundh, Thomas ; Chen, Wei J. ; Lee, Wen-Chung ; Hsiao, Chuhsing Kate ; Chien, Kuo-Liong ; Kuo, Po-Hsiu ; Hung, Hung ; Liao, Shu-Fen ; EnviroGenomarkers Consortium. / DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia. In: Environment International. 2019 ; Vol. 126. pp. 24-36.

@article{bcce5a07e0954db987ff16a3480ca4ac,

title = "DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia",

keywords = "Molecular epidemiology, Persistent organic pollutants, DNA methylation, B-cell lymphoma, Environmental toxicology, Hazard assessment, PERSISTENT ORGANIC POLLUTANTS, POLYCHLORINATED BIPHENYL EXPOSURES, POLYCOMB, GENES, RISK, LYMPHOMA, CANCER, ROLES, HYPERMETHYLATION, HYPOMETHYLATION",

author = "Panagiotis Georgiadis and Marios Gavriil and Panu Rantakokko and Efthymios Ladoukakis and Maria Botsivali and Kelly, {Rachel S.} and Bergdahl, {Ingvar A.} and Hannu Kiviranta and Vermeulen, {Roel C. H.} and Florentin Spaeth and Hebbels, {Dennie G. A. J.} and Kleinjans, {Jos C. S.} and {de Kok}, {Theo M. C. M.} and Domenico Palli and Paolo Vineis and Kyrtopoulos, {Soterios A.} and Ralph Gottschalk and {van Leeuwen}, Danitsja and Leen Timmermans and Benedetta Bendinelli and Lutzen Portengen and Fatemeh Saberi-Hosnijeh and Beatrice Melin and Goran Hallmans and Per Lenner and Keun, {Hector C.} and Alexandros Siskos and Athersuch, {Toby J.} and Manolis Kogevinas and Stephanou, {Euripides G.} and Antonis Myridakis and Lucia Fazzo and {De Santis}, Marco and Pietro Comba and Riikka Airaksinen and Paivi Ruokojarvi and Mark Gilthorpe and Sarah Fleming and Thomas Fleming and Yu-Kang Tu and Bo Jonsson and Thomas Lundh and Chen, {Wei J.} and Wen-Chung Lee and Hsiao, {Chuhsing Kate} and Kuo-Liong Chien and Po-Hsiu Kuo and Hung Hung and Shu-Fen Liao and {EnviroGenomarkers Consortium}",

year = "2019",

month = may,

doi = "10.1016/j.envint.2019.01.068",

language = "English",

volume = "126",

pages = "24--36",

journal = "Environment International",

issn = "0160-4120",

publisher = "Elsevier Science",

}

Georgiadis, P, Gavriil, M, Rantakokko, P, Ladoukakis, E, Botsivali, M, Kelly, RS, Bergdahl, IA, Kiviranta, H, Vermeulen, RCH, Spaeth, F, Hebbels, DGAJ, Kleinjans, JCS, de Kok, TMCM, Palli, D, Vineis, P, Kyrtopoulos, SA, Gottschalk, R, van Leeuwen, D, Timmermans, L, Bendinelli, B, Portengen, L, Saberi-Hosnijeh, F, Melin, B, Hallmans, G, Lenner, P, Keun, HC, Siskos, A, Athersuch, TJ, Kogevinas, M, Stephanou, EG, Myridakis, A, Fazzo, L, De Santis, M, Comba, P, Airaksinen, R, Ruokojarvi, P, Gilthorpe, M, Fleming, S, Fleming, T, Tu, Y-K, Jonsson, B, Lundh, T, Chen, WJ, Lee, W-C, Hsiao, CK, Chien, K-L, Kuo, P-H, Hung, H, Liao, S-F & EnviroGenomarkers Consortium 2019, 'DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia', Environment International, vol. 126, pp. 24-36. https://doi.org/10.1016/j.envint.2019.01.068

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia. / Georgiadis, Panagiotis; Gavriil, Marios; Rantakokko, Panu; Ladoukakis, Efthymios; Botsivali, Maria; Kelly, Rachel S.; Bergdahl, Ingvar A.; Kiviranta, Hannu; Vermeulen, Roel C. H.; Spaeth, Florentin; Hebbels, Dennie G. A. J.; Kleinjans, Jos C. S.; de Kok, Theo M. C. M.; Palli, Domenico; Vineis, Paolo; Kyrtopoulos, Soterios A.; Gottschalk, Ralph; van Leeuwen, Danitsja; Timmermans, Leen; Bendinelli, Benedetta; Portengen, Lutzen; Saberi-Hosnijeh, Fatemeh; Melin, Beatrice; Hallmans, Goran; Lenner, Per; Keun, Hector C.; Siskos, Alexandros; Athersuch, Toby J.; Kogevinas, Manolis; Stephanou, Euripides G.; Myridakis, Antonis; Fazzo, Lucia; De Santis, Marco; Comba, Pietro; Airaksinen, Riikka; Ruokojarvi, Paivi; Gilthorpe, Mark; Fleming, Sarah; Fleming, Thomas; Tu, Yu-Kang; Jonsson, Bo; Lundh, Thomas; Chen, Wei J.; Lee, Wen-Chung; Hsiao, Chuhsing Kate; Chien, Kuo-Liong; Kuo, Po-Hsiu; Hung, Hung; Liao, Shu-Fen; EnviroGenomarkers Consortium.

In: Environment International, Vol. 126, 05.2019, p. 24-36.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

AU - Georgiadis, Panagiotis

AU - Gavriil, Marios

AU - Rantakokko, Panu

AU - Ladoukakis, Efthymios

AU - Botsivali, Maria

AU - Kelly, Rachel S.

AU - Bergdahl, Ingvar A.

AU - Kiviranta, Hannu

AU - Vermeulen, Roel C. H.

AU - Spaeth, Florentin

AU - Hebbels, Dennie G. A. J.

AU - Kleinjans, Jos C. S.

AU - de Kok, Theo M. C. M.

AU - Palli, Domenico

AU - Vineis, Paolo

AU - Kyrtopoulos, Soterios A.

AU - Gottschalk, Ralph

AU - van Leeuwen, Danitsja

AU - Timmermans, Leen

AU - Bendinelli, Benedetta

AU - Portengen, Lutzen

AU - Saberi-Hosnijeh, Fatemeh

AU - Melin, Beatrice

AU - Hallmans, Goran

AU - Lenner, Per

AU - Keun, Hector C.

AU - Siskos, Alexandros

AU - Athersuch, Toby J.

AU - Kogevinas, Manolis

AU - Stephanou, Euripides G.

AU - Myridakis, Antonis

AU - Fazzo, Lucia

AU - De Santis, Marco

AU - Comba, Pietro

AU - Airaksinen, Riikka

AU - Ruokojarvi, Paivi

AU - Gilthorpe, Mark

AU - Fleming, Sarah

AU - Fleming, Thomas

AU - Tu, Yu-Kang

AU - Jonsson, Bo

AU - Lundh, Thomas

AU - Chen, Wei J.

AU - Lee, Wen-Chung

AU - Hsiao, Chuhsing Kate

AU - Chien, Kuo-Liong

AU - Kuo, Po-Hsiu

AU - Hung, Hung

AU - Liao, Shu-Fen

AU - EnviroGenomarkers Consortium

PY - 2019/5

Y1 - 2019/5

KW - Molecular epidemiology

KW - Persistent organic pollutants

KW - DNA methylation

KW - B-cell lymphoma

KW - Environmental toxicology

KW - Hazard assessment

KW - PERSISTENT ORGANIC POLLUTANTS

KW - POLYCHLORINATED BIPHENYL EXPOSURES

KW - POLYCOMB

KW - GENES

KW - RISK

KW - LYMPHOMA

KW - CANCER

KW - ROLES

KW - HYPERMETHYLATION

KW - HYPOMETHYLATION

U2 - 10.1016/j.envint.2019.01.068

DO - 10.1016/j.envint.2019.01.068

M3 - Article

C2 - 30776747

VL - 126

SP - 24

EP - 36

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -