DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial

Raghav Sundar; Alvin Ng; Hermioni Zouridis; Nisha Padmanabhan; Taotao Sheng; Shenli Zhang; Ming Hui Lee; Wen Fong Ooi; Aditi Qamra; Imran Inam; Lindsay C. Hewitt; Jimmy Bok-Yan So; Vivien Koh; Matthew G. Nankivell; Ruth E. Langley; William H. Allum; David Cunningham; Steven G. Rozen; Wei Peng Yong; Heike I. Grabsch; Patrick Tan

doi:10.1016/j.ejca.2019.09.016

DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial

Raghav Sundar, Alvin Ng, Hermioni Zouridis, Nisha Padmanabhan, Taotao Sheng, Shenli Zhang, Ming Hui Lee, Wen Fong Ooi, Aditi Qamra, Imran Inam, Lindsay C. Hewitt, Jimmy Bok-Yan So, Vivien Koh, Matthew G. Nankivell, Ruth E. Langley, William H. Allum, David Cunningham, Steven G. Rozen, Wei Peng Yong, Heike I. GrabschPatrick Tan

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	48-57
Number of pages	10
Journal	European Journal of Cancer
Volume	123
DOIs	https://doi.org/10.1016/j.ejca.2019.09.016
Publication status	Published - Dec 2019

Keywords

Epigenetic signature
DNA methylation
Predictive biomarker
Chemotherapy
Oesophageal adenocarcinoma
GASTRIC-CANCER
OPEN-LABEL
PERIOPERATIVE CHEMOTHERAPY
METHYLATION
CAPECITABINE
RESECTION
SURGERY

Cite this

Sundar, R., Ng, A., Zouridis, H., Padmanabhan, N., Sheng, T., Zhang, S., Lee, M. H., Ooi, W. F., Qamra, A., Inam, I., Hewitt, L. C., So, J. B-Y., Koh, V., Nankivell, M. G., Langley, R. E., Allum, W. H., Cunningham, D., Rozen, S. G., Yong, W. P., ... Tan, P. (2019). DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial. European Journal of Cancer, 123, 48-57. https://doi.org/10.1016/j.ejca.2019.09.016

Sundar, Raghav ; Ng, Alvin ; Zouridis, Hermioni ; Padmanabhan, Nisha ; Sheng, Taotao ; Zhang, Shenli ; Lee, Ming Hui ; Ooi, Wen Fong ; Qamra, Aditi ; Inam, Imran ; Hewitt, Lindsay C. ; So, Jimmy Bok-Yan ; Koh, Vivien ; Nankivell, Matthew G. ; Langley, Ruth E. ; Allum, William H. ; Cunningham, David ; Rozen, Steven G. ; Yong, Wei Peng ; Grabsch, Heike I. ; Tan, Patrick. / DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma : results from the MRC OE02 trial. In: European Journal of Cancer. 2019 ; Vol. 123. pp. 48-57.

@article{cb6fad8a4f0644a9985b9bbb2b910442,

title = "DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial",

keywords = "Epigenetic signature, DNA methylation, Predictive biomarker, Chemotherapy, Oesophageal adenocarcinoma, GASTRIC-CANCER, OPEN-LABEL, PERIOPERATIVE CHEMOTHERAPY, METHYLATION, CAPECITABINE, RESECTION, SURGERY",

author = "Raghav Sundar and Alvin Ng and Hermioni Zouridis and Nisha Padmanabhan and Taotao Sheng and Shenli Zhang and Lee, {Ming Hui} and Ooi, {Wen Fong} and Aditi Qamra and Imran Inam and Hewitt, {Lindsay C.} and So, {Jimmy Bok-Yan} and Vivien Koh and Nankivell, {Matthew G.} and Langley, {Ruth E.} and Allum, {William H.} and David Cunningham and Rozen, {Steven G.} and Yong, {Wei Peng} and Grabsch, {Heike I.} and Patrick Tan",

year = "2019",

month = dec

doi = "10.1016/j.ejca.2019.09.016",

language = "English",

volume = "123",

pages = "48--57",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "ELSEVIER SCI LTD",

}

Sundar, R, Ng, A, Zouridis, H, Padmanabhan, N, Sheng, T, Zhang, S, Lee, MH, Ooi, WF, Qamra, A, Inam, I, Hewitt, LC, So, JB-Y, Koh, V, Nankivell, MG, Langley, RE, Allum, WH, Cunningham, D, Rozen, SG, Yong, WP, Grabsch, HI & Tan, P 2019, 'DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial', European Journal of Cancer, vol. 123, pp. 48-57. https://doi.org/10.1016/j.ejca.2019.09.016

DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma : results from the MRC OE02 trial. / Sundar, Raghav; Ng, Alvin; Zouridis, Hermioni; Padmanabhan, Nisha; Sheng, Taotao; Zhang, Shenli; Lee, Ming Hui; Ooi, Wen Fong; Qamra, Aditi; Inam, Imran; Hewitt, Lindsay C.; So, Jimmy Bok-Yan; Koh, Vivien; Nankivell, Matthew G.; Langley, Ruth E.; Allum, William H.; Cunningham, David; Rozen, Steven G.; Yong, Wei Peng; Grabsch, Heike I.; Tan, Patrick.

In: European Journal of Cancer, Vol. 123, 12.2019, p. 48-57.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma

T2 - results from the MRC OE02 trial

AU - Sundar, Raghav

AU - Ng, Alvin

AU - Zouridis, Hermioni

AU - Padmanabhan, Nisha

AU - Sheng, Taotao

AU - Zhang, Shenli

AU - Lee, Ming Hui

AU - Ooi, Wen Fong

AU - Qamra, Aditi

AU - Inam, Imran

AU - Hewitt, Lindsay C.

AU - So, Jimmy Bok-Yan

AU - Koh, Vivien

AU - Nankivell, Matthew G.

AU - Langley, Ruth E.

AU - Allum, William H.

AU - Cunningham, David

AU - Rozen, Steven G.

AU - Yong, Wei Peng

AU - Grabsch, Heike I.

AU - Tan, Patrick

PY - 2019/12

Y1 - 2019/12

KW - Epigenetic signature

KW - DNA methylation

KW - Predictive biomarker

KW - Chemotherapy

KW - Oesophageal adenocarcinoma

KW - GASTRIC-CANCER

KW - OPEN-LABEL

KW - PERIOPERATIVE CHEMOTHERAPY

KW - METHYLATION

KW - CAPECITABINE

KW - RESECTION

KW - SURGERY

U2 - 10.1016/j.ejca.2019.09.016

DO - 10.1016/j.ejca.2019.09.016

M3 - Article

VL - 123

SP - 48

EP - 57

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

ER -

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10.1016/j.ejca.2019.09.016