DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients

Y.M. Jonkers; S.M.H. Claessen; A. Perren; A.M. Schmitt; L.J. Hofland; W.W. de Herder; R.R. de Krijger; A.A. Verhofstad; A.R. Hermus; J.A. Kummer; B. Skogseid; M. Volante; A.C. Voogd; F.C.S. Ramaekers; E.J.M. Speel

doi:10.1677/ERC-07-0111

DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients

Y.M. Jonkers^*, S.M.H. Claessen, A. Perren, A.M. Schmitt, L.J. Hofland, W.W. de Herder, R.R. de Krijger, A.A. Verhofstad, A.R. Hermus, J.A. Kummer, B. Skogseid, M. Volante, A.C. Voogd, F.C.S. Ramaekers, E.J.M. Speel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict in the absence of metastases or invasion to adjacent organs. Several markers have been indicated as potential predictors of metastatic disease, such as tumor size >= 2cm, Ki67 proliferative index 2%, cytokeratin (CK) 19 status, and recently in insulinomas, chromosomal instability (CIN). The goal of this study was to evaluate the value of these markers, and in particular of the CIN, to predict tumor recurrence or progression and tumor-specific death, using a series of 47 insulinomas and 24 noninsulinoma EPTs. From these EPT cases, a genomic profile has been generated and follow-up data have been obtained. The proliferative index has been determined in 68 tumors and a CK1 9 expression pattern in 50 tumors. Results are statistically analyzed using Kaplan-Meier plots and the log-rank statistic. General CIN, as well as specific chromosomal alterations such as 3p and 6q loss and 12q gain, turned out to be the most powerful indicators for poor tumor-free survival (P = 2% were reliable in predicting a poor tumor-f ree survival in noninsulinoma EPTs (P

Original language	English
Pages (from-to)	769-79
Journal	Endocrine-Related Cancer
Volume	14
Issue number	3
DOIs	https://doi.org/10.1677/ERC-07-0111
Publication status	Published - 1 Jan 2007

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Jonkers, Y. M., Claessen, S. M. H., Perren, A., Schmitt, A. M., Hofland, L. J., de Herder, W. W., de Krijger, R. R., Verhofstad, A. A., Hermus, A. R., Kummer, J. A., Skogseid, B., Volante, M., Voogd, A. C., Ramaekers, F. C. S., & Speel, E. J. M. (2007). DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients. Endocrine-Related Cancer, 14(3), 769-79. https://doi.org/10.1677/ERC-07-0111

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title = "DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients",

abstract = "The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict in the absence of metastases or invasion to adjacent organs. Several markers have been indicated as potential predictors of metastatic disease, such as tumor size >= 2cm, Ki67 proliferative index 2%, cytokeratin (CK) 19 status, and recently in insulinomas, chromosomal instability (CIN). The goal of this study was to evaluate the value of these markers, and in particular of the CIN, to predict tumor recurrence or progression and tumor-specific death, using a series of 47 insulinomas and 24 noninsulinoma EPTs. From these EPT cases, a genomic profile has been generated and follow-up data have been obtained. The proliferative index has been determined in 68 tumors and a CK1 9 expression pattern in 50 tumors. Results are statistically analyzed using Kaplan-Meier plots and the log-rank statistic. General CIN, as well as specific chromosomal alterations such as 3p and 6q loss and 12q gain, turned out to be the most powerful indicators for poor tumor-free survival (P = 2% were reliable in predicting a poor tumor-f ree survival in noninsulinoma EPTs (P ",

author = "Y.M. Jonkers and S.M.H. Claessen and A. Perren and A.M. Schmitt and L.J. Hofland and {de Herder}, W.W. and {de Krijger}, R.R. and A.A. Verhofstad and A.R. Hermus and J.A. Kummer and B. Skogseid and M. Volante and A.C. Voogd and F.C.S. Ramaekers and E.J.M. Speel",

year = "2007",

month = jan,

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doi = "10.1677/ERC-07-0111",

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Jonkers, YM, Claessen, SMH, Perren, A, Schmitt, AM, Hofland, LJ, de Herder, WW, de Krijger, RR, Verhofstad, AA, Hermus, AR, Kummer, JA, Skogseid, B, Volante, M, Voogd, AC , Ramaekers, FCS & Speel, EJM 2007, 'DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients', Endocrine-Related Cancer, vol. 14, no. 3, pp. 769-79. https://doi.org/10.1677/ERC-07-0111

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T1 - DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients

AU - Jonkers, Y.M.

AU - Claessen, S.M.H.

AU - Perren, A.

AU - Schmitt, A.M.

AU - Hofland, L.J.

AU - de Herder, W.W.

AU - de Krijger, R.R.

AU - Verhofstad, A.A.

AU - Hermus, A.R.

AU - Kummer, J.A.

AU - Skogseid, B.

AU - Volante, M.

AU - Voogd, A.C.

AU - Ramaekers, F.C.S.

AU - Speel, E.J.M.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict in the absence of metastases or invasion to adjacent organs. Several markers have been indicated as potential predictors of metastatic disease, such as tumor size >= 2cm, Ki67 proliferative index 2%, cytokeratin (CK) 19 status, and recently in insulinomas, chromosomal instability (CIN). The goal of this study was to evaluate the value of these markers, and in particular of the CIN, to predict tumor recurrence or progression and tumor-specific death, using a series of 47 insulinomas and 24 noninsulinoma EPTs. From these EPT cases, a genomic profile has been generated and follow-up data have been obtained. The proliferative index has been determined in 68 tumors and a CK1 9 expression pattern in 50 tumors. Results are statistically analyzed using Kaplan-Meier plots and the log-rank statistic. General CIN, as well as specific chromosomal alterations such as 3p and 6q loss and 12q gain, turned out to be the most powerful indicators for poor tumor-free survival (P = 2% were reliable in predicting a poor tumor-f ree survival in noninsulinoma EPTs (P

AB - The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict in the absence of metastases or invasion to adjacent organs. Several markers have been indicated as potential predictors of metastatic disease, such as tumor size >= 2cm, Ki67 proliferative index 2%, cytokeratin (CK) 19 status, and recently in insulinomas, chromosomal instability (CIN). The goal of this study was to evaluate the value of these markers, and in particular of the CIN, to predict tumor recurrence or progression and tumor-specific death, using a series of 47 insulinomas and 24 noninsulinoma EPTs. From these EPT cases, a genomic profile has been generated and follow-up data have been obtained. The proliferative index has been determined in 68 tumors and a CK1 9 expression pattern in 50 tumors. Results are statistically analyzed using Kaplan-Meier plots and the log-rank statistic. General CIN, as well as specific chromosomal alterations such as 3p and 6q loss and 12q gain, turned out to be the most powerful indicators for poor tumor-free survival (P = 2% were reliable in predicting a poor tumor-f ree survival in noninsulinoma EPTs (P

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DO - 10.1677/ERC-07-0111

M3 - Article

C2 - 17914106

SN - 1351-0088

VL - 14

SP - 769

EP - 779

JO - Endocrine-Related Cancer

JF - Endocrine-Related Cancer

IS - 3

ER -

DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients

Abstract

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