DLK1, a serum marker for hepatoblastoma in young infants.

F.A. Falix; D.C. Aronson; W.H. Lamers; J.K. Hiralall; J. Seppen

doi:10.1002/pbc.24024

DLK1, a serum marker for hepatoblastoma in young infants.

F.A. Falix
, D.C. Aronson
, W.H. Lamers
, J.K. Hiralall
, J. Seppen^*

^*Corresponding author for this work

Anatomie & Embryologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, a-fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta-like 1 homolog (DLK1), a protein highly expressed during fetal development, but almost completely absent after birth, and an established liver-stem cell marker, is a new candidate serum marker of hepatoblastoma, especially in young infants. Pediatr Blood Cancer 2012;59:743745. (c) 2011 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	743-745
Number of pages	3
Journal	Pediatric Blood & Cancer
Volume	59
Issue number	4
DOIs	https://doi.org/10.1002/pbc.24024
Publication status	Published - Oct 2012

Keywords

DLK1
hepatoblastoma
serum marker
CHILDHOOD HEPATOBLASTOMA
LIVER-TUMORS
PROTEIN DLK
EXPRESSION
CHILDREN

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10.1002/pbc.24024

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title = "DLK1, a serum marker for hepatoblastoma in young infants.",

abstract = "Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, a-fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta-like 1 homolog (DLK1), a protein highly expressed during fetal development, but almost completely absent after birth, and an established liver-stem cell marker, is a new candidate serum marker of hepatoblastoma, especially in young infants. Pediatr Blood Cancer 2012;59:743745. (c) 2011 Wiley Periodicals, Inc.",

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author = "F.A. Falix and D.C. Aronson and W.H. Lamers and J.K. Hiralall and J. Seppen",

year = "2012",

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doi = "10.1002/pbc.24024",

language = "English",

volume = "59",

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T1 - DLK1, a serum marker for hepatoblastoma in young infants.

AU - Falix, F.A.

AU - Aronson, D.C.

AU - Lamers, W.H.

AU - Hiralall, J.K.

AU - Seppen, J.

PY - 2012/10

Y1 - 2012/10

N2 - Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, a-fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta-like 1 homolog (DLK1), a protein highly expressed during fetal development, but almost completely absent after birth, and an established liver-stem cell marker, is a new candidate serum marker of hepatoblastoma, especially in young infants. Pediatr Blood Cancer 2012;59:743745. (c) 2011 Wiley Periodicals, Inc.

AB - Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, a-fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta-like 1 homolog (DLK1), a protein highly expressed during fetal development, but almost completely absent after birth, and an established liver-stem cell marker, is a new candidate serum marker of hepatoblastoma, especially in young infants. Pediatr Blood Cancer 2012;59:743745. (c) 2011 Wiley Periodicals, Inc.

KW - DLK1

KW - hepatoblastoma

KW - serum marker

KW - CHILDHOOD HEPATOBLASTOMA

KW - LIVER-TUMORS

KW - PROTEIN DLK

KW - EXPRESSION

KW - CHILDREN

U2 - 10.1002/pbc.24024

DO - 10.1002/pbc.24024

M3 - Article

C2 - 22180200

SN - 1545-5009

VL - 59

SP - 743

EP - 745

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

IS - 4

ER -

DLK1, a serum marker for hepatoblastoma in young infants.

Abstract

Keywords

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