DLK1, a serum marker for hepatoblastoma in young infants.

F.A. Falix, D.C. Aronson, W.H. Lamers, J.K. Hiralall, J. Seppen

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Abstract

Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, a-fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta-like 1 homolog (DLK1), a protein highly expressed during fetal development, but almost completely absent after birth, and an established liver-stem cell marker, is a new candidate serum marker of hepatoblastoma, especially in young infants. Pediatr Blood Cancer 2012;59:743745. (c) 2011 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)743-745
Number of pages3
JournalPediatric Blood & Cancer
Volume59
Issue number4
DOIs
Publication statusPublished - Oct 2012

Keywords

  • DLK1
  • hepatoblastoma
  • serum marker
  • CHILDHOOD HEPATOBLASTOMA
  • LIVER-TUMORS
  • PROTEIN DLK
  • EXPRESSION
  • CHILDREN

Cite this

Falix, F. A., Aronson, D. C., Lamers, W. H., Hiralall, J. K., & Seppen, J. (2012). DLK1, a serum marker for hepatoblastoma in young infants. Pediatric Blood & Cancer, 59(4), 743-745. https://doi.org/10.1002/pbc.24024