Abstract
Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, a-fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta-like 1 homolog (DLK1), a protein highly expressed during fetal development, but almost completely absent after birth, and an established liver-stem cell marker, is a new candidate serum marker of hepatoblastoma, especially in young infants. Pediatr Blood Cancer 2012;59:743745. (c) 2011 Wiley Periodicals, Inc.
Original language | English |
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Pages (from-to) | 743-745 |
Number of pages | 3 |
Journal | Pediatric Blood & Cancer |
Volume | 59 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 2012 |
Keywords
- DLK1
- hepatoblastoma
- serum marker
- CHILDHOOD HEPATOBLASTOMA
- LIVER-TUMORS
- PROTEIN DLK
- EXPRESSION
- CHILDREN