Abstract
Alzheimer's disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of Aβ plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High Aβ plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of Aβ plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of Aβ plaques were located in the amygdala, and the cerebellum; but no Aβ plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of Aβ plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of Aβ deposition in the brain and its inter-regional correlation. This suggests an association between Aβ plaque deposition and specific brain regions in AD pathogenesis.
Original language | English |
---|---|
Article number | 964336 |
Number of pages | 19 |
Journal | Frontiers in Aging Neuroscience |
Volume | 14 |
DOIs | |
Publication status | Published - 28 Jul 2022 |
Keywords
- 5xFAD
- Alzheimer's disease
- CONNECTIVITY
- DORSOLATERAL PERIAQUEDUCTAL GRAY
- ELECTRICAL-STIMULATION
- HIPPOCAMPUS
- HYPOTHALAMUS
- MEMORY
- NEURODEGENERATION
- NUCLEUS
- SPATIAL WORKING
- TRANSGENIC MICE
- amyloid-beta (AB)
- dementia
- morphology
- neuroanatomy