Distributed cortical systems in visual shortterm memory revealed by eventrelated functional magnetic resonance imaging.

M.E. Munk, D.E. Linden, L.F. Muckli, H. Lanfermann, F.E. Zanella, W. Singer, R.W. Goebel

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Abstract

The spatio-temporal distribution of brain activity as revealed by non-invasive functional imaging helps to elucidate the neuronal encoding and processing strategies required by complex cognitive tasks. We investigated visual short-term memory for objects, places and conjunctions in humans using event-related time-resolved functional magnetic resonance imaging that permitted segregation of encoding, retention and retrieval phases. All conditions were accompanied by the activation of a widespread network of parietal and prefrontal areas during the retention phase, but this retention-related activity showed additional modulations depending on task instructions. These modulations confirmed a posterior - anterior and right - left dissociation for spatial versus non-spatial memory and revealed that conjunction memory does not rely on a linear addition of the component processes.
Original languageEnglish
Pages (from-to)866-876
JournalCerebral Cortex
Volume12
DOIs
Publication statusPublished - 1 Jan 2002

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