Distinct Ethnic Differences in Lipid Profiles across Glucose Categories

L. Zhang, Q. Qiao*, J. Tuomilehto, E.D. Janus, T.H. Lam, A. Ramachandran, V. Mohan, C.D. Stehouwer, Y. Dong, T. Nakagami, A. Onat, S. Soderberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Context: Dyslipidemia coexists with hyperglycemia. However, little is known about the ethnic differences in lipid profiles at comparable glucose tolerance status. Objective: The aim was to study ethnic differences in lipid profiles stratified by glucose levels. Design and Setting: Data from 31 study cohorts of 12 countries, consisting of 24,760 men and 27,595 women aged 25-74 yr, were compared. The odds ratio for having dyslipidemia was estimated for each ethnic group stratified by glucose categories. Results: Compared with central and northern Europeans, multivariable adjusted odds ratios (95% confidence intervals) for having lower high-density lipoprotein-cholesterol were 4.74 (4.19-5.37), 5.05 (3.88-6.56), 3.07 (2.15-4.40), and 2.37 (1.67-3.35) in Asian Indian men, but 0.12 (0.09-0.16), 0.07 (0.04-0.13), 0.11 (0.07-0.20), and 0.16 (0.08-0.32) in Chinese men who had normoglycemia, prediabetes, and undiagnosed and diagnosed diabetes, respectively. Similar results were obtained for women. The prevalence of low high-density lipoprotein-cholesterol remained higher in Asian Indians (62.8% of the nondiabetic and 67.4% of the diabetic) than in central and northern Europeans (20.3 and 37.3%), Japanese (25.7 and 34.1%), or Qingdao Chinese (15.7 and 17.0%), even in individuals with low-density lipoprotein-cholesterol of less than 3 mmol/liter. Conclusion: There are distinct patterns of lipid profiles associated with ethnicity regardless of the glucose levels, suggesting that ethnic-specific strategies and guidelines on risk assessment and prevention of cardiovascular disease are required.
Original languageEnglish
Pages (from-to)1793-1801
Number of pages9
JournalJournal of Clinical Endocrinology & Metabolism
Volume95
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • DENSITY-LIPOPROTEIN CHOLESTEROL
  • CARDIOVASCULAR RISK-FACTORS
  • ASIAN INDIAN WOMEN
  • DIABETES-MELLITUS
  • HDL-CHOLESTEROL
  • INSULIN-RESISTANCE
  • HIGH PREVALENCE
  • PRIOR HISTORY
  • POPULATION
  • DISEASE

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