Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity

Karma Pearce*, Alicia Hatzinikolas, Lisa Moran, Maximilian P. J. de Courten, Josephine Forbes, Jean L. J. M. Scheijen, Casper G. Schalkwijk, Karen Walker, Barbora de Courten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

We have previously shown that an isoenergetic low advanced glycation end products (AGEs) diet matched for macronutrient content improved insulin sensitivity compared to high AGE diet. Here, we evaluated the differences in micronutrient intake of these two dietary patterns and if they could explain differences in insulin sensitivity. Participants consumed the intervention diets each for 2weeks with 4weeks of habitual dietary intake (washout) in-between. Dietary analysis revealed that the high AGE diet contained greater levels of retinol equivalents (RE) (478.9+151.3g/day versus 329.0+170.0g/day; p.1) therefore are unlikely to explain observed changes in insulin sensitivity. (clinicaltrials.gov:NCT00422253).

Original languageEnglish
Pages (from-to)1021-1026
Number of pages6
JournalInternational Journal of Food Sciences and Nutrition
Volume68
Issue number8
DOIs
Publication statusPublished - 2017

Keywords

  • Advanced glycation end products (AGEs)
  • ageing
  • chronic disease
  • lifestyle disease
  • LIPID-PEROXIDATION
  • DOUBLE-BLIND
  • FOODS
  • GLYCOXIDATION
  • INDIVIDUALS
  • DISEASES
  • STRESS
  • TRIAL
  • FAT

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