Disorders of lipid metabolism in 3 patients with diabetes mellitus type 2

B.H.R. Wolffenbuttel, M.S.P. Huijberts

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Disorders of lipid metabolism in 3 patients with diabetes mellitus type 2]

[Article in Dutch]

Wolffenbuttel BH, Huijberts MS.

Academisch Ziekenhuis, afd. Endocrinologie, Postbus 5800, 6202 AZ Maastrict. bwo@sint.azm.nl

Three patients with diabetes mellitus (type 2) and cardiovascular disease had disturbed lipid concentrations: two women aged 60 and 73 years and one man aged 47 years. The lipid levels were normalised during the 9-18 years of treatment with medication and in this period the patients experienced no cardiovascular events. Disturbances in plasma lipid levels play a major role in the increased risk of cardiovascular disease in patients with diabetes mellitus (type 2). Cholesterol-lowering treatment should be aggressive and based on the lipid profile. Statins reduce cardiovascular events by lowering the concentration of both the total cholesterol and low-density lipoprotein cholesterol whereas fibrates reduce cardiovascular events by increasing high-density lipoprotein cholesterol concentrations and lowering triglyceride concentrations.
Original languageEnglish
Pages (from-to)761-765
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Volume145
Publication statusPublished - 1 Jan 2001

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