Discrimination of Healthy and Glaucomatous Eyes Based on the Ocular Pulse Amplitude: A Diagnostic Case-Control Study

Yves C. A. Robert; Andreas Wild; Alfons G. Kessels; Walter H. Backes; Andreas Zollinger; Lucas M. Bachmann

doi:10.1159/000334616

Discrimination of Healthy and Glaucomatous Eyes Based on the Ocular Pulse Amplitude: A Diagnostic Case-Control Study

Yves C. A. Robert^*, Andreas Wild, Alfons G. Kessels, Walter H. Backes, Andreas Zollinger, Lucas M. Bachmann

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Web of Science)

Abstract

By measuring the ocular pulse amplitude (OPA), the dynamic contour tonometer (DCT) assesses intraocular pressure (IOP). Hypothesizing that OPA is characteristic for the IOP when considered with the systemic arterial blood pressure, we assumed the ratio of ocular and arterial pulsation amplitudes is larger in glaucoma patients. Bi-ocular DCT-OPA assessment was synchronized with arterial pulsations using Finapres (R) technology, thereby enabling blood pressure determination for each corresponding IOP value every 0.01 s for 12 s. Based on measurements and calculations in 10 healthy subjects and 11 glaucoma patients, we conclude that the ratio of the OPA and blood pressure variances is a strong glaucoma diagnostic indicator, thereby justifying further investigation.

Original language	English
Pages (from-to)	1-5
Journal	Ophthalmic Research
Volume	48
Issue number	1
DOIs	https://doi.org/10.1159/000334616
Publication status	Published - 2012

Keywords

Glaucoma
Ocular pulse amplitude
Dynamic contour tonometer
Finapres (R)

Access to Document

10.1159/000334616

Cite this

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title = "Discrimination of Healthy and Glaucomatous Eyes Based on the Ocular Pulse Amplitude: A Diagnostic Case-Control Study",

abstract = "By measuring the ocular pulse amplitude (OPA), the dynamic contour tonometer (DCT) assesses intraocular pressure (IOP). Hypothesizing that OPA is characteristic for the IOP when considered with the systemic arterial blood pressure, we assumed the ratio of ocular and arterial pulsation amplitudes is larger in glaucoma patients. Bi-ocular DCT-OPA assessment was synchronized with arterial pulsations using Finapres (R) technology, thereby enabling blood pressure determination for each corresponding IOP value every 0.01 s for 12 s. Based on measurements and calculations in 10 healthy subjects and 11 glaucoma patients, we conclude that the ratio of the OPA and blood pressure variances is a strong glaucoma diagnostic indicator, thereby justifying further investigation. ",

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AU - Robert, Yves C. A.

AU - Wild, Andreas

AU - Kessels, Alfons G.

AU - Backes, Walter H.

AU - Zollinger, Andreas

AU - Bachmann, Lucas M.

PY - 2012

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AB - By measuring the ocular pulse amplitude (OPA), the dynamic contour tonometer (DCT) assesses intraocular pressure (IOP). Hypothesizing that OPA is characteristic for the IOP when considered with the systemic arterial blood pressure, we assumed the ratio of ocular and arterial pulsation amplitudes is larger in glaucoma patients. Bi-ocular DCT-OPA assessment was synchronized with arterial pulsations using Finapres (R) technology, thereby enabling blood pressure determination for each corresponding IOP value every 0.01 s for 12 s. Based on measurements and calculations in 10 healthy subjects and 11 glaucoma patients, we conclude that the ratio of the OPA and blood pressure variances is a strong glaucoma diagnostic indicator, thereby justifying further investigation.

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KW - Ocular pulse amplitude

KW - Dynamic contour tonometer

KW - Finapres (R)

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