Discrimination of Healthy and Glaucomatous Eyes Based on the Ocular Pulse Amplitude: A Diagnostic Case-Control Study

Yves C. A. Robert*, Andreas Wild, Alfons G. Kessels, Walter H. Backes, Andreas Zollinger, Lucas M. Bachmann

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)


By measuring the ocular pulse amplitude (OPA), the dynamic contour tonometer (DCT) assesses intraocular pressure (IOP). Hypothesizing that OPA is characteristic for the IOP when considered with the systemic arterial blood pressure, we assumed the ratio of ocular and arterial pulsation amplitudes is larger in glaucoma patients. Bi-ocular DCT-OPA assessment was synchronized with arterial pulsations using Finapres (R) technology, thereby enabling blood pressure determination for each corresponding IOP value every 0.01 s for 12 s. Based on measurements and calculations in 10 healthy subjects and 11 glaucoma patients, we conclude that the ratio of the OPA and blood pressure variances is a strong glaucoma diagnostic indicator, thereby justifying further investigation.
Original languageEnglish
Pages (from-to)1-5
JournalOphthalmic Research
Issue number1
Publication statusPublished - 2012


  • Glaucoma
  • Ocular pulse amplitude
  • Dynamic contour tonometer
  • Finapres (R)

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