Discrepancy between Lung Function Measurements at Home and in the Hospital in Children with Asthma and CF

Frederick L. G. R. Gerzon, Quirijn Jobsis, Michiel A. G. E. Bannier, Bjorn Winkens, Edward Dompeling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The Coronavirus pandemic stresses the importance of eHealth techniques to monitor patients at home. Home monitoring of lung function in asthma and cystic fibrosis (CF) may help to detect deterioration of lung function at an early stage, but the reliability is unclear. We investigated whether lung function measurements at home were comparable to measurements during clinical visits. We analysed prospectively collected data of two one-year observational cohort studies in 117 children (36 with CF and 81 with asthma). All patients performed forced expiratory volume in one second (FEV1) measurements with a monitor at home. Paired FEV(1)measurements were included if the measurement on the home monitor was performed on the same day as the FEV(1)measurement on the pneumotachometer during a two monthly clinical visit. Bland-Altman plots and linear mixed model analysis were used. The mean difference (home measurement was subtracted from clinical measurement) in FEV(1)was 0.18 L in CF (95% confidence interval (CI) 0.08-0.27 L;p<0.001) and 0.12 L in asthma (95%CI 0.05-0.19 L;p<0.001). FEV(1)measurements at home were significantly lower than clinically obtained FEV(1)measurements, which has implications for the application of this technique in the daily clinical situation.

Original languageEnglish
Article number1617
Number of pages9
JournalJournal of Clinical Medicine
Issue number6
Publication statusPublished - Jun 2020


  • home monitoring
  • lung function
  • asthma
  • cystic fibrosis
  • children
  • telemedicine
  • FLOW

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