Discovering the nucleus in a world of biomaterials

Steven Vermeulen; Elizabeth Rosado Balmayor

doi:10.1016/j.bbiosy.2024.100096

Discovering the nucleus in a world of biomaterials

Steven Vermeulen
, Elizabeth Rosado Balmayor^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The nucleus serves as the central hub for cellular activity, driving cell identity and behavior. Despite its crucial role, understanding how biomaterials influence the nucleus remains an underexplored area of research. In our opinion, this is an overlooked opportunity, particularly in regenerative medicine — a field where cellular control is not just beneficial, but essential. As such, we emphasize the need to recognize nuclear characteristics as a key metric for evaluating material functionality. In this leading opinion article, we discuss how state-of-the-art technologies can help reveal biomaterial-driven nuclear alterations, offering crucial insights that will advance the field of regenerative medicine.

Original language	English
Article number	100096
Number of pages	3
Journal	Biomaterials and Biosystems
Volume	14
DOIs	https://doi.org/10.1016/j.bbiosy.2024.100096
Publication status	Published - 1 Jun 2024

Keywords

Advanced technologies
Biomaterial-driven nuclear alterations
Mechanobiology
Surface topography

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10.1016/j.bbiosy.2024.100096Licence: CC BY

Cite this

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title = "Discovering the nucleus in a world of biomaterials",

abstract = "The nucleus serves as the central hub for cellular activity, driving cell identity and behavior. Despite its crucial role, understanding how biomaterials influence the nucleus remains an underexplored area of research. In our opinion, this is an overlooked opportunity, particularly in regenerative medicine — a field where cellular control is not just beneficial, but essential. As such, we emphasize the need to recognize nuclear characteristics as a key metric for evaluating material functionality. In this leading opinion article, we discuss how state-of-the-art technologies can help reveal biomaterial-driven nuclear alterations, offering crucial insights that will advance the field of regenerative medicine.",

keywords = "Advanced technologies, Biomaterial-driven nuclear alterations, Mechanobiology, Surface topography",

author = "Steven Vermeulen and Balmayor, \{Elizabeth Rosado\}",

note = "Funding Information: S.V. thanks the Gravitation Program of the Netherlands Organization for Scientific Research (NWO) (project 'Materials-Driven Regeneration'; grant no. 024.003.013 ). E.R.B. thanks for the support of NIH , grant R01 AR074395 from NIAMS. This work was supported by the Open Access Publishing Agreement \textbackslash{}u201CProjekt DEAL\textbackslash{}u201D between German Universities and Elsevier. Publisher Copyright: {\textcopyright} 2024",

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doi = "10.1016/j.bbiosy.2024.100096",

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AU - Vermeulen, Steven

AU - Balmayor, Elizabeth Rosado

N1 - Funding Information: S.V. thanks the Gravitation Program of the Netherlands Organization for Scientific Research (NWO) (project 'Materials-Driven Regeneration'; grant no. 024.003.013 ). E.R.B. thanks for the support of NIH , grant R01 AR074395 from NIAMS. This work was supported by the Open Access Publishing Agreement \u201CProjekt DEAL\u201D between German Universities and Elsevier. Publisher Copyright: © 2024

PY - 2024/6/1

Y1 - 2024/6/1

N2 - The nucleus serves as the central hub for cellular activity, driving cell identity and behavior. Despite its crucial role, understanding how biomaterials influence the nucleus remains an underexplored area of research. In our opinion, this is an overlooked opportunity, particularly in regenerative medicine — a field where cellular control is not just beneficial, but essential. As such, we emphasize the need to recognize nuclear characteristics as a key metric for evaluating material functionality. In this leading opinion article, we discuss how state-of-the-art technologies can help reveal biomaterial-driven nuclear alterations, offering crucial insights that will advance the field of regenerative medicine.

AB - The nucleus serves as the central hub for cellular activity, driving cell identity and behavior. Despite its crucial role, understanding how biomaterials influence the nucleus remains an underexplored area of research. In our opinion, this is an overlooked opportunity, particularly in regenerative medicine — a field where cellular control is not just beneficial, but essential. As such, we emphasize the need to recognize nuclear characteristics as a key metric for evaluating material functionality. In this leading opinion article, we discuss how state-of-the-art technologies can help reveal biomaterial-driven nuclear alterations, offering crucial insights that will advance the field of regenerative medicine.

KW - Advanced technologies

KW - Biomaterial-driven nuclear alterations

KW - Mechanobiology

KW - Surface topography

U2 - 10.1016/j.bbiosy.2024.100096

DO - 10.1016/j.bbiosy.2024.100096

M3 - Article

SN - 2666-5344

VL - 14

JO - Biomaterials and Biosystems

JF - Biomaterials and Biosystems

M1 - 100096

ER -

Discovering the nucleus in a world of biomaterials

Abstract

Keywords

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